EVALUATION OF THE ACUTE AND SUBCHRONIC TOXICITY OF ZIWAN BAIBU TANG
| Autor: | Luo Chaoying, Wen-jing Peng, Ge Liang, Li Jinyu, Xie Jiasheng, Xin Ruihua, Ji-fang Zheng, Wang Guibo, Xiao-lei Liu, Yong-jiang Luo |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
business.industry
Subacute toxicity Physiology Pharmacology Creatine Body weight Serum urea Subchronic toxicity Red blood cell chemistry.chemical_compound medicine.anatomical_structure Complementary and alternative medicine chemistry Drug Discovery Toxicity medicine Respiratory system business Ziwan Baibu Tang acute subchronic toxicity herbal |
| Zdroj: | African Journal of Traditional, Complementary and Alternative Medicines; Vol 13, No 3 (2016); 140-149 |
| ISSN: | 2505-0044 0189-6016 |
| Popis: | Background: Ziwan Baibu Tang (ZBT) is used as a traditional Chinese prescription used in the clinic to cure a variety of respiratory diseases. The objective of this study was to evaluate the acute and subacute toxicity of ZBT. Materials and Methods: Fifty Kunming mice were assigned to 5 groups, and ZBT was administered at different concentrations. Symptoms, mortality and behavioural changes were recorded. Eighty Wistar rats were randomly allocated to 4 treatment groups or a control group for 4 weeks of treatment (half male and half female); general observations and weekly body weight (BW) gain were recorded. At the end of the 4-week experiment, the rats were sacrificed, and blood was collected for haematological and serum biochemical analyses. Samples from the primary organs were fixed in 10% buffered formalin for histopathological studies. Results: The calculated LD50 of acute oral toxicity was 319.16 g/kg BW. After the 4-week treatment, BW did not significantly differ in any of the dose groups, compared with the control group (P>0.05), and the rat blood red blood cell (RBC) and haemoglobin (HGB) levels in each dose group did not significantly differ (P>0.05). In addition, serum urea and creatine levels in each dose group did not significantly differ from those in the control group (P>0.05). Conclusion: These results indicate that ZBT does not possess toxic potential and that both the acute and subchronic toxicity in animals are very low. |
| Databáze: | OpenAIRE |
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