Association Of Serum Pentraxin-3 And High-Sensitivity C-Reactive Protein With The Extent Of Coronary Stenosis In Patients Undergoing Coronary Angiography
| Autor: | Vesna Vukovic-Dejanovic, Natasa Bogavac-Stanojevic, Dimitra Kalimanovska-Ostric, Slavica Spasic, Mirko Topalovic, Zorana Jelic-Ivanovic, Vesna Spasojevic-Kalimanovska |
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| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Coronary angiography
medicine.medical_specialty CAD 030204 cardiovascular system & hematology Coronary artery disease lcsh:Biochemistry 03 medical and health sciences dijagnostička tačnost 0302 clinical medicine pentraksin-3 Internal medicine medicine lcsh:QD415-436 030212 general & internal medicine cardiovascular diseases Subclinical infection Original Paper pentraxin3 high sensitivity C-reactive protein biology visokoosetljivi C-reaktivni protein business.industry C-reactive protein nutritional and metabolic diseases PTX3 koronarna arterijska bolest medicine.disease 3. Good health Stenosis pentraxin-3 Cardiology biology.protein diagnostic accuracy business Risk assessment coronary artery disease |
| Zdroj: | Journal of Medical Biochemistry, Vol 34, Iss 4, Pp 440-449 (2015) Journal of Medical Biochemistry Journal of Medical Biochemistry (2015) 34(4):440-449 |
| ISSN: | 1452-8266 1452-8258 |
| Popis: | We compared factors of inflammation - high sensitivity C-reactive protein (hsCRP) and pentraxin-3 (PTX3), and we explored their relationship with coronary artery disease (CAD). Also, we tested the usefulness of hsCRP and PTX3 in the risk assessment of coronary stenosis development and the diagnostic ability of these biomarkers to detect disease severity.The study group consisted of 93 CAD patients undergoing coronary angiography. Patients were divided into CAD(0), representing subclinical stenosis, and CAD (1-3), representing significant stenosis in one, two or three vessels.We determined the concentration of lipid status parameters, hsCRP and PTX3. We found significantly lower PTX3 and hsCRP concentrations in CAD(0) than in CAD(1-3) group. Concentration of PTX3 showed an increasing trend with the increasing number of vessels affected. The area under ROC curve (AUC) for the combinations of hsCRP and PTX3 with lipid parameters had useful accuracy for detecting CAD(1-3) patients (AUC=0.770,PTX3 is a promising independent diagnostic marker for identifying patients with CAD, and a useful indicator of disease progression. In all the analyses PTX3 showed better performance than hsCRP. A combination of PTX3, hsCRP with the lipid status parameters provides risk stratification of the development of coronary stenosis and better classification than their individual application.Visokoosetljivi C-reaktivni protein (hsCRP), kao marker hronične inflamacije, može biti korišćen u proceni rizika od kardiovaskularnih bolesti. Cilj rada je bio da se uporede markeri inflamacije hsCRP i pentraksin-3 (PTX3) i da se ispita njihova veza sa koronarnom arterijskom bolešću (KAB). Takođe, analiziran je značaj hsCRP i PTX3 u proceni rizika za koronarnu stenozu i dijagnostička sposobnost ovih biomarkera da utvrde težinu bolesti.Istraživanjem je obuhvaćeno 93 pacijenta koji su podvrgnuti koronarnoj angiografiji. Pacijenti sa subkliničkom stenozom na koronarnim krvnim sudovima svrstani su u KAB(0) grupu, dok su pacijenti sa značajnom stenozom na jednom, dva ili tri krvna suda svrstani u KAB(1–3) grupu. Određivane su koncentracije parametara lipidnog statusa, hsCRP i PTX3.Prosečne koncentracije PTX3 i hsCRP kod pacijenata u KAB(0) grupi bile su značajno niže u poređenju sa koncentracijama istih parametara u KAB(1–3) grupi. Koncentracija PTX3 pokazala je značajnu pozitivnu korelaciju sa porastom broja krvnih sudova zahvaćenih stenozom. Površina ispodOdređivanje PTX3 pomaže u identifikaciji osoba sa KAB i može biti korisno u proceni progresije bolesti. U svim analizama PTX3 je, kao biomarker, pokazao bolje dijagnostičke karakteristike u poređenju sa hsCRP. Kombinacija PTX3, hsCRP i parametara lipidnog statusa, u poređenju sa njihovom pojedinačnom upotrebom, obezbeđuje bolju klasifikaciju pacijenata u zavisnosti od težine KAB. |
| Databáze: | OpenAIRE |
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