Splicing diversity revealed by reduced spliceosomes in C. merolae and other organisms
| Autor: | Naomi M. Fast, Anthony G. Russell, Martha R. Stark, Andrew J. Hudson, Stephen D. Rader |
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| Rok vydání: | 2015 |
| Předmět: |
Spliceosome
reduced spliceosome intron RNA Splicing medicine.disease_cause Catalysis small nuclear RNA Evolution Molecular RNA Small Nuclear microsporidian evolution medicine RNA Precursors Animals Humans snRNP Molecular Biology Point of View Genetics biology Intron Protist Cell Biology biology.organism_classification Introns alga Cyanidioschyzon merolae Evolutionary biology RNA splicing Rhodophyta Spliceosomes Giardia lamblia spliceosome protist spliceosome catalytic core spliceosome diversity Small nuclear RNA |
| Zdroj: | RNA Biology |
| ISSN: | 1555-8584 |
| Popis: | Pre-mRNA splicing has been considered one of the hallmarks of eukaryotes, yet its diversity is astonishing: the number of substrate introns for splicing ranges from hundreds of thousands in humans to a mere handful in certain parasites. The catalytic machinery that carries out splicing, the spliceosome, is similarly diverse, with over 300 associated proteins in humans to a few tens in other organisms. In this Point of View, we discuss recent work characterizing the reduced spliceosome of the acidophilic red alga Cyanidioschyzon merolae, which further highlights the diversity of splicing in that it does not possess the U1 snRNP that is characteristically responsible for 5' splice site recognition. Comparisons to other organisms with reduced spliceosomes, such as microsporidia, trypanosomes, and Giardia, help to identify the most highly conserved splicing factors, pointing to the essential core of this complex machine. These observations argue for increased exploration of important biochemical processes through study of a wider ranger of organisms. |
| Databáze: | OpenAIRE |
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