Bariatric Surgery for Monogenic Non-syndromic and Syndromic Obesity Disorders
| Autor: | Lotte Kleinendorst, Kasper W. ter Horst, Mieke M. van Haelst, Johannes A. Romijn, Mellody I. Cooiman, Sabrina M. Oussaada, Mireille J. Serlie, Eric J. Hazebroek, Marcel M.A.M. Mannens, Niels Vos |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Genetics (AP Morris Section Editor) Endocrinology Diabetes and Metabolism 030209 endocrinology & metabolism MC4R Morbid obesity 03 medical and health sciences Human health 0302 clinical medicine Diabetes mellitus Genetics Prevalence Internal Medicine Humans Mass Screening Medicine Obesity Limited evidence Bariatric surgery business.industry PWS Treatment options medicine.disease Syndromic obesity Obesity Morbid Surgery 030104 developmental biology business Non syndromic |
| Zdroj: | Current Diabetes Reports Vos, N, Oussaada, S M, Cooiman, M I, Kleinendorst, L, ter Horst, K W, Hazebroek, E J, Romijn, J A, Serlie, M J, Mannens, M M A M & van Haelst, M M 2020, ' Bariatric Surgery for Monogenic Non-syndromic and Syndromic Obesity Disorders ', Current Diabetes Reports, vol. 20, no. 9, 44 . https://doi.org/10.1007/s11892-020-01327-7 |
| ISSN: | 1539-0829 1534-4827 |
| DOI: | 10.1007/s11892-020-01327-7 |
| Popis: | Purpose of Review The global prevalence of obesity has increased rapidly over the last decades, posing a severe threat to human health. Currently, bariatric surgery is the most effective therapy for patients with morbid obesity. It is unknown whether this treatment is also suitable for patients with obesity due to a confirmed genetic defect (genetic obesity disorders). Therefore, this review aims to elucidate the role of bariatric surgery in the treatment of genetic obesity. Recent Findings In monogenic non-syndromic obesity, an underlying genetic defect seems to be the most important factor determining the efficacy of bariatric surgery. In syndromic obesity, bariatric surgery result data are scarce, and even though some promising follow-up results have been reported, caution is required as patients with more severe behavioral and developmental disorders might have poorer outcomes. Summary There is limited evidence in support of bariatric surgery as a treatment option for genetic obesity disorders; hence, no strong statements can be made regarding the efficacy and safety of these procedures for these patients. However, considering that patients with genetic obesity often present with life-threatening obesity-related comorbidities, we believe that bariatric surgery could be considered a last-resort treatment option in selected patients. |
| Databáze: | OpenAIRE |
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