Pre-clinical investigations of β-carboline alkaloids as antidepressant agents: A systematic review
| Autor: | Raimundo Gonçalves de Oliveira Júnior, Jackson Roberto Guedes da Silva Almeida, Xirley Pereira Nunes, Christiane Adrielly Alves Ferraz, Laurent Picot |
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| Přispěvatelé: | Universidade Federal do Vale do Sao Francisco (UNIVASF), LIttoral ENvironnement et Sociétés - UMRi 7266 (LIENSs), Université de La Rochelle (ULR)-Centre National de la Recherche Scientifique (CNRS) |
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Drug Evaluation
Preclinical Bioinformatics 01 natural sciences chemistry.chemical_compound Alkaloids Harmine [SDV.SP.MED]Life Sciences [q-bio]/Pharmaceutical sciences/Medication In vivo Mild stress Drug Discovery Animals Medicine [SDV.BBM.BC]Life Sciences [q-bio]/Biochemistry Molecular Biology/Biochemistry [q-bio.BM] Methodological quality Pharmacology Depression 010405 organic chemistry business.industry General Medicine Antidepressive Agents In vitro 3. Good health 0104 chemical sciences 010404 medicinal & biomolecular chemistry chemistry Antidepressant business Carbolines |
| Zdroj: | Fitoterapia Fitoterapia, Elsevier, 2019, 137, pp.104196. ⟨10.1016/j.fitote.2019.104196⟩ |
| ISSN: | 0367-326X 1873-6971 |
| DOI: | 10.1016/j.fitote.2019.104196⟩ |
| Popis: | International audience; Depressive disorders remain a current public health problem whose prevalence has increased in the past decades. In the constant search for new therapeutic alternatives, β-carboline alkaloids have been identified as good candidates for new antidepressant drugs. In this systematic review, we summarized all pre-clinical investigations involving the use of natural or semisynthetic β-carboline in depression models. A literature search was conducted in August 2018, using PubMed, Scopus and Science Direct databases. All reports were carefully analyzed, and data extraction was conducted through standardized forms. Methodological quality assessment of in vivo studies was also performed. The entire systematic review was performed according to PRISMA statement. From a total of 373 articles, 26 met all inclusion criteria. In vitro and in vivo studies have evaluated a wide variety of β-carbolines through enzymatic and binding assays, and acute or chronic animal models. Most of the in vivo and in vitro studies is concentrated on two molecules: harman and harmine. They have been investigated in several animal models and some mechanisms of action have been proposed for their antidepressant activity. In general, β-carbolines modulate 5-HT and GABA systems, promote neurogenesis, induce neuroendocrine response and restore astrocytic function, being effective when administrated acutely or chronically in different animal models, including chronic mild stress protocols. In short, β-carbolines are multi-target antidepressant compounds and may be useful in the treatment of depressive disorders. |
| Databáze: | OpenAIRE |
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