Integrated RFA/PSOCT catheter for real-time guidance of cardiac radio-frequency ablation
| Autor: | Michael W. Jenkins, Christopher S. Snyder, Xiaoyong Fu, Andrew M. Rollins, Yves T. Wang, Colin Blumenthal, Xiaowei Zhao, Mauricio Arruda |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Radiofrequency ablation
medicine.medical_treatment 030204 cardiovascular system & hematology 01 natural sciences Article law.invention 010309 optics 03 medical and health sciences 0302 clinical medicine Optical coherence tomography law 0103 physical sciences medicine Direct monitoring medicine.diagnostic_test business.industry Magnetic resonance imaging Ablation Atomic and Molecular Physics and Optics Catheter Polarization sensitive surgical procedures operative Radio frequency business therapeutics Biotechnology Biomedical engineering |
| Popis: | Radiofrequency ablation (RFA) is an important standard therapy for cardiac arrhythmias, but direct monitoring of tissue treatment is currently lacking. We demonstrate an RFA catheter integrated with polarization sensitive optical coherence tomography (PSOCT) for directly monitoring the RFA process in real time. The integrated RFA/OCT catheter was modified from a standard clinical RFA catheter and includes a miniature forward-viewing cone-scanning OCT probe. The PSOCT system was validated with a quarter-wave plate while the RFA function of the integrated catheter was validated by comparing lesion sizes with those made with an unmodified RFA catheter. Additionally, the integrated catheter guided catheter-tissue apposition and monitored RFA lesion formation in cardiac tissue in real time. The results show that catheter-tissue contact can be characterized by observing the features of the blood and tissue in the acquired OCT images and that RFA lesion formation can be confirmed by monitoring the change in phase retardance in the acquired PSOCT images. This system demonstrates the feasibility of an integrated RFA/OCT catheter to deliver RF energy and image the cardiac wall simultaneously and justifies further research into use of this technology to aid RFA therapy for cardiac arrhythmias. |
| Databáze: | OpenAIRE |
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