Absence of antibody to HTLV I and III in sera of Canadian patients with multiple sclerosis and chronic myelopathy
| Autor: | George P.A. Rice, George C. Ebers, D. E. Bulman, H. Armstrong, Donald W. Paty |
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| Předmět: |
Canada
Multiple Sclerosis viruses Chronic myelopathy Antibodies Viral Deltaretrovirus Spinal Cord Diseases Myelopathy Immunopathology Tropical spastic paraparesis medicine Humans Deltaretrovirus Infections biology business.industry Multiple sclerosis HIV medicine.disease Virology Neurology Immunology Chronic Disease biology.protein Neurology (clinical) Viral disease Enzyme immunoassays Antibody Nervous System Diseases business |
| Zdroj: | Scopus-Elsevier |
| Popis: | Recently, elevated titers of antibody to HTLV I have been demonstrated in patients with tropical spastic paraparesis and multiple sclerosis. We evaluated the possible role of human retroviruses HTLV I and III in Canadian patients with multiple sclerosis and chronic idiopathic myelopathy. Using sensitive enzyme immunoassays, we were unable to find antibody to either HTLV I or III in 201 patients with multiple sclerosis, 29 patients with chronic myelopathy, 51 patients with other neurological disorders, or 29 normal subjects. These data do not support a role for these viruses in the cause of sporadic multiple sclerosis and chronic myelopathy in a regionally based Canadian population, but do not exclude a role for other antigenically distinct retroviruses. |
| Databáze: | OpenAIRE |
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