Pathophysiology and therapeutic possibilities of calcitonin gene-related peptide in hypertension
| Autor: | Gloria Balfagón, Iván Márquez-Rodas, Federico Longo, R. P. Rothlin |
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| Rok vydání: | 2006 |
| Předmět: |
medicine.medical_specialty
Angiotensin receptor Physiology Calcitonin Gene-Related Peptide Calcitonin gene-related peptide Pharmacology Biochemistry Preeclampsia Pre-Eclampsia Pregnancy Internal medicine medicine Animals Humans Vasospasm Intracranial biology business.industry Vasospasm Angiotensin-converting enzyme General Medicine Rutaecarpine Genetic Therapy medicine.disease Endocrinology Calcitonin Pathophysiology of hypertension Hypertension biology.protein Female business Receptors Calcitonin Gene-Related Peptide |
| Zdroj: | Journal of physiology and biochemistry. 62(1) |
| ISSN: | 1138-7548 |
| Popis: | Calcitonin gene related peptide (CGRP), a 37 amino acid neuropeptide, is the most potent vasodilator known. Participation of CGRP in hypertension and related diseases, such as preeclampsia or vasospasm after subarachnoid haemorrage, is one of the most studied topics. In this review we summarize the published roles of CGRP in pathophysiology of hypertension in humans and in experimental models. We also discuss the effects of direct administration of CGRP in the treatment of hypertension and of anti-hypertensive drugs that enhance the release or response of endogenous calcitonin gene-related peptide: angiotensin converting enzyme inhibitors, selective antagonists for the angiotensin II receptor, beta-blockers, magnesium sulphate for preeclampsia and rutaecarpine, as well as the possibilities using CGRP in gene therapy for prevention of vasospasm after subarachnoid haemorrage. |
| Databáze: | OpenAIRE |
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