Oral manifestations, salivary flow rates and Candida species in Thai HIV-infected patients
| Autor: | Oitip Chankanka, Kraisorn Sappayatosok, Piamkamon Vacharotayangul, Sorasun Rungsiyanont, Aroonwan Lam-ubol |
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| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Saliva medicine.medical_specialty 030106 microbiology 03 medical and health sciences 0302 clinical medicine Acquired immunodeficiency syndrome (AIDS) immune system diseases Internal medicine Hiv infected patients Medicine 030212 general & internal medicine General Dentistry Colony-forming unit Oral Medicine and Pathology business.industry Research virus diseases CIENCIAS MÉDICAS [UNESCO] medicine.disease Antiretroviral therapy Hyperpigmentation Corpus albicans Sensitivity test UNESCO::CIENCIAS MÉDICAS medicine.symptom business |
| Zdroj: | Lam-ubol, Aroonwan ; Rungsiyanont, Sorasun ; Vacharotayangul, Piamkamon ; Sappayatosok, Kraisorn ; Chankanka, Oitip. Oral manifestations, salivary flow rates and Candida species in Thai HIV-infected patients. En: Journal of Clinical and Experimental Dentistry, 11 2 2019: 138-145 RODERIC. Repositorio Institucional de la Universitat de Valéncia instname Journal of Clinical and Experimental Dentistry |
| Popis: | Background Effects of various Highly Active Antiretroviral Therapy (HAART) regimens on oral heath are unclear. Objectives: We aimed to evaluate effects of HAART on oral manifestations, salivary flow rates (SFR) and Candida species in HIV-infected patients who took mostly non-protease inhibitor-based HAART regimens. Material and methods A cross-sectional study was performed on HIV-infected patients taking and never taken HAART who attended Thai Red Cross AIDS Research Centre (n = 48). Non-HIV subjects were recruited as control (n = 20). Oral conditions and salivary flow rates were evaluated using oral examination and measurement of unstimulated and stimulated saliva. In addition, Candida colonization counts (colony forming units; CFUs) and Candida species from the collected saliva were evaluated using CHROMagar. Results The most common oral manifestation in HIV-infected subjects taking HAART was hyperpigmentation. Unstimulated and stimulated SFR among the three groups were not statistically significant. Candida colonization was detected in 64%, 65% and 35% of HIV-infected subjects taking HAART, HAART-naive, and non-HIV subjects, respectively. While 20% and 35% of HIV-infected subjects with and without HAART, respectively, had Candida CFUs higher than 500/ml, all non-HIV carriers had Candida CFUs lower than 500/ml. The most common Candida colonization species was C. albicans in HAART and non-HIV groups. Interestingly, HAART-naive group was colonized more by non-albicans species. Conclusions HAART has minimal effects on oral health. While HAART may not prevent Candida colonization, it might lead to reduction of non-albicans species. Because maintaining low Candida counts is important, HAART administration and antifungal sensitivity test should be considered in HIV-infected patients. Key words:HIV, Candida, HAART, Oral manifestation, Salivary flow rates. |
| Databáze: | OpenAIRE |
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