Defects in mandibular bone area, enamel iron content and dentine formation following gastrectomy in rats
| Autor: | Shigeru Saitoh, Yuka Hirama, Ryuji Sasa, Tomio Morohashi, Shoji Yamada, Sawa Takahara, Atsutane Ohta, Tsuneyoshi Sano |
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| Rok vydání: | 2002 |
| Předmět: |
Male
Iron medicine.medical_treatment Statistics as Topic Dentistry Parathyroid hormone Mandible Bone resorption Rats Sprague-Dawley Malabsorption Syndromes stomatognathic system Gastrectomy Maxilla medicine Animals Bone Resorption Dental Enamel General Dentistry Fluorescent Dyes Anemia Iron-Deficiency Enamel paint medicine.diagnostic_test business.industry Chemistry Cell Biology General Medicine Dentinogenesis Tetracycline Fluoresceins Rats Incisor Microscopy Electron stomatognathic diseases Apposition medicine.anatomical_structure Microscopy Fluorescence Otorhinolaryngology Parathyroid Hormone visual_art Dentin visual_art.visual_art_medium Serum iron Calcium business Cancellous bone Electron Probe Microanalysis |
| Zdroj: | Archives of Oral Biology. 47:499-504 |
| ISSN: | 0003-9969 |
| DOI: | 10.1016/s0003-9969(02)00016-x |
| Popis: | Fourteen 5-week-old male Sprague–Dawley rats were equally divided into two groups, sham-operated and gastrectomized. Tetracycline and calcein were given to label dentine. Four weeks after surgery, blood was collected for measurement of serum iron, calcium and parathyroid hormone (PTH) and the mandibles and maxillae were then removed. Sagittal sections of the maxilla or cross-sections of the mandible were prepared and examined. Backscattered electron images of the maxilla were taken and the iron content at the neck of incisors was measured by energy-dispersive X-ray. The dentine apposition rate in maxillary incisors was measured by fluorescence microscopy. Serum iron was significantly decreased, while PTH was significantly elevated without any change in the serum calcium in gastrectomized rats. Gastrectomy caused a gross loss of iron content in superficial enamel. The dentine apposition rate was significantly reduced by 30%. Both cortical and cancellous bone in the mandibula were significantly reduced. However, the total bone area in gastrectomized rats was similar to that in sham-operated rats. These results suggest that bone resorption was enhanced and dentine formation was reduced after gastrectomy. |
| Databáze: | OpenAIRE |
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