Diet-Induced Obesity and Circadian Disruption of Feeding Behavior
| Autor: | Alexandra N. Garcia, Susanne E. la Fleur, Jorge E. Mendoza, Aurea Susana Blancas-Velazquez |
|---|---|
| Přispěvatelé: | Institut des Neurosciences Cellulaires et Intégratives (INCI), Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS), University of Amsterdam [Amsterdam] (UvA), Netherlands Institute for Neuroscience (NIN), Royal Netherlands Academy of Arts and Sciences (KNAW) |
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty obesity Period (gene) Review Biology 03 medical and health sciences Reward system 0302 clinical medicine palatable Dopamine Internal medicine clock-genes medicine Journal Article Ingestion Circadian rhythm hypothalamus reward Suprachiasmatic nucleus General Neuroscience [SDV.MHEP.EM]Life Sciences [q-bio]/Human health and pathology/Endocrinology and metabolism CLOCK 030104 developmental biology Endocrinology circadian Hypothalamus dopamine [SDV.AEN]Life Sciences [q-bio]/Food and Nutrition 030217 neurology & neurosurgery feeding medicine.drug Neuroscience |
| Zdroj: | Frontiers in Neuroscience Frontiers in Neuroscience, Frontiers, 2017, 11, pp.23. ⟨10.3389/fnins.2017.00023⟩ Frontiers in Neuroscience, 11. Frontiers Media SA |
| ISSN: | 1662-4548 1662-453X |
| Popis: | International audience; Feeding behavior shows a rhythmic daily pattern, which in nocturnal rodents is observed mainly during the dark period. This rhythmicity is under the influence of the hypothalamic suprachiasmatic nucleus (SCN), the main biological clock. Nevertheless, various studies have shown that in rodent models of obesity, using high-energy diets, the general locomotor activity and feeding rhythms can be disrupted. Here, we review the data on the effects of diet-induced obesity (DIO) on locomotor activity and feeding patterns, as well as the effect on the brain sites within the neural circuitry involved in metabolic and rewarding feeding behavior. In general, DIO may alter locomotor activity by decreasing total activity. On the other hand, DIO largely alters eating patterns, producing increased overall ingestion and number of eating bouts that can extend to the resting period. Furthermore, within the hypothalamic areas, little effect has been reported on the molecular circadian mechanism in DIO animals with ad libitum hypercaloric diets and little or no data exist so far on its effects on the reward system areas. We further discuss the possibility of an uncoupling of metabolic and reward systems in DIO and highlight a gap of circadian and metabolic research that may help to better understand the implications of obesity |
| Databáze: | OpenAIRE |
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