Solid organ transplantation for non-TTR hereditary amyloidosis: report from the 1st International Workshop on the Hereditary Renal Amyloidoses
| Autor: | Reinhold P. Linke, Steven R. Zeldenrust, Arie J. Stangou, Bernard Portmann, Maria M. Picken, Bo Goran Ericzon, John O'Grady, Gerd Otto, Luísa Lobato, Henryk Wilczek, Gilles Grateau, Mohamed Rela, Ole B. Suhr, Daniel Azoulay, Nigel Heaton, Isabel Conceição, Merrill D. Benson |
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| Rok vydání: | 2012 |
| Předmět: |
medicine.medical_specialty
Pathology Systemic disease medicine.medical_treatment Liver transplantation Organ transplantation Renal amyloidosis Internal Medicine Medicine Humans biology Apolipoprotein A-I business.industry Amyloidosis Fibrinogen Organ Transplantation medicine.disease Liver Transplantation Transplantation Transthyretin Treatment Outcome Immunology biology.protein business Nephrotic syndrome Amyloidosis Familial |
| Zdroj: | Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis. 19 |
| ISSN: | 1744-2818 |
| Popis: | Fibrinogen A α-chain (AFib) and apolipoprotein AI (AApoAI) amyloidosis due to variants in the AFib and ApoAI genes are the most common types of hereditary amyloidosis in Europe and the United States. Liver is the exclusive source of the aberrant amyloidogenic protein in AFib and responsible for supplying approximately half of the circulating variant ApoAI. Nephrotic syndrome and renal impairment due to renal amyloidosis are common disease manifestations; however, recent research provides evidence to support a more diverse and systemic disease phenotype, which in turn has implications in the management of the hereditary amyloidoses with solid organ transplantation and, in particular, liver transplantation. |
| Databáze: | OpenAIRE |
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