Urinary cytology: a potential tool for differential diagnosis of acute kidney injury in patients with nephrotic syndrome

Autor:	Marília Bahiense Oliveira, Carlos Alberto dos Santos Silva, Caroline Vilas Boas de Melo, Maria Brandão Tavares, Paula Neves Fernandes, Ricardo David Couto, Washington Luis Conrado dosSantos
Rok vydání:	2020
Předmět:	0301 basic medicine medicine.medical_specialty Nephrotic Syndrome Cytodiagnosis Kidney Glomerulus Urology lcsh:Medicine urologic and male genital diseases General Biochemistry Genetics and Molecular Biology Diagnosis Differential 03 medical and health sciences 0302 clinical medicine Glomerulonephritis Biopsy medicine Rapidly progressive glomerulonephritis Humans 030212 general & internal medicine lcsh:Science (General) Acute tubular necrosis lcsh:QH301-705.5 Urine cytology medicine.diagnostic_test business.industry urogenital system lcsh:R Acute kidney injury General Medicine Acute Kidney Injury Kidney Tubular Necrosis Acute medicine.disease female genital diseases and pregnancy complications Research Note 030104 developmental biology lcsh:Biology (General) Renal biopsy business Nephrotic syndrome lcsh:Q1-390
Zdroj:	BMC Research Notes BMC Research Notes, Vol 13, Iss 1, Pp 1-6 (2020)
ISSN:	1756-0500
Popis:	Objective Acute tubular necrosis (ATN) is a frequent cause of acute kidney injury (AKI). In patients with nephrotic syndrome (NS), AKI demands the differential diagnosis between ATN and rapidly progressive glomerulonephritis. In some cases, conclusive diagnosis is possible only by kidney biopsy. We aimed to study the potential use of urine cytology in the differential diagnosis between ATN and proliferative glomerular lesion in patients with NS. Results Cell size analysis showed a higher proportion of small cells and a lower proportion of large cells in the urine of patients with AKI. Cells phenotypes were easily defined using cytological preparations. Leukocytes were found to be a primary classifier of NS groups, with higher number in patients with AKI and patients with proliferative glomerular lesions. Although renal biopsy is still required for confirmative diagnosis, our data suggests that urinary cytology can be readily performed and support the differential diagnosis between proliferative glomerular lesion and ATN in patients with NS and AKI.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5bb26ad9e9cff882379ace5095810f84 https://pubmed.ncbi.nlm.nih.gov/32854763 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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