The Interaction of GLUT1 and FOXM1 Leads to a Poor Prognosis in Colorectal Cancer
| Autor: | Zhi-Yi Lei, Xiao-Yi Kuai, Xiao-Shuang Liu, Xinyu Shao |
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| Rok vydání: | 2019 |
| Předmět: |
Male
Cancer Research Colorectal cancer Carbohydrate metabolism Metastasis 03 medical and health sciences 0302 clinical medicine Medicine Humans Stage (cooking) 030304 developmental biology Pharmacology 0303 health sciences Glucose Transporter Type 1 biology business.industry Forkhead Box Protein M1 Glucose transporter Middle Aged medicine.disease Immunohistochemistry digestive system diseases 030220 oncology & carcinogenesis Cancer research FOXM1 biology.protein Molecular Medicine GLUT1 Female business Colorectal Neoplasms |
| Zdroj: | Anti-cancer agents in medicinal chemistry. 20(8) |
| ISSN: | 1875-5992 |
| Popis: | Background: Colorectal Cancer (CRC) is one of the most common fatal diseases with high morbidity. Alteration of glucose metabolism is one of the hallmarks in the development of CRC. Glucose Transporter 1 (GLUT1) is a key rate-limiting protein in hyperactive glucose metabolism and up-regulated in CRC, however, the underlying mechanism of the altered metabolism in CRC is still unknown. Methods: In this study, immunohistochemical staining was used to evaluate the expression of GLUT1 and FOXM1 in 135 paired CRC and adjacent normal tissues. The association between the expression of GLUT1/FOXM1 and clinicopathological factors was determined and the correlation between GLUT1 and FOXM1 in CRC was investigated. Results: Our results revealed that regardless of tumor location, GLUT1 and FOXM1 were overexpressed in CRC tissues, especially in patients with positive lymph node metastasis and TNM stage III-IV. Furthermore, GLUT1 showed a significantly strong link with FOXM1 in CRC tissue. Conclusions: Overexpression of GLUT1 and FOXM1 may play critical roles in CRC leading to a poor prognosis. |
| Databáze: | OpenAIRE |
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