Effect of thymic extract on allogeneic MLR and mitogen-induced responses in patients with chronic active hepatitis B
| Autor: | E. Majewska, Pokoca L, Krzysztof Zeman, Dworniak D, H Tchórzewski |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Adult
Lymphocyte T-Lymphocytes Immunology CD4-CD8 Ratio medicine.disease_cause Lymphocyte Activation Thymus Extracts Virus Immunophenotyping medicine Humans Lymphocytes Hepatitis Chronic Hepatitis Hepatitis B virus Immunity Cellular biology Chronic Active Antibodies Monoclonal General Medicine medicine.disease biology.organism_classification Mixed lymphocyte reaction Hepatitis B medicine.anatomical_structure Hepadnaviridae Lymphocyte Culture Test Mixed Mitogens CD8 |
| Zdroj: | Immunological investigations. 20(7) |
| ISSN: | 0882-0139 |
| Popis: | Cell-mediated immune reactions are involved in the development of chronic active hepatitis (CAH-B). The present studies confirm that lymphocyte from patients with CAH-B have a decreased aliogeneic mixed lymphocyte reaction (allo-MLR) and mitogen-induced responses. These abnormalities probably play a role in the immunological dysfunctions underlying chronic liver diseases. Twenty one patients with biopsy-proven CAH-B and a significantly lowered CD4:CD8 cell number ratio were treated with thymic extract (Thymomodulin-TFX) for 6 months. The results of immunological, serological and biochemical findings indicate that this preparation has an immunoregulatory action and produces beneficial clinical effect in patients with CAH-B. |
| Databáze: | OpenAIRE |
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