Efficacy of levetiracetam for migraine prophylaxis: A systematic review and meta-analysis
| Autor: | Po Hua Yen, Chien Tai Hong, Ka Wai Tam, Yi Chun Kuan, Yao Hsien Huang, Chen Chih Chung |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Levetiracetam Migraine Disorders Migraine prophylaxis Antiepileptic drugs Placebo law.invention 03 medical and health sciences 0302 clinical medicine Randomized controlled trial law Internal medicine Headache disorders medicine Humans Prospective Studies Prospective cohort study Adverse effect lcsh:R5-920 business.industry Headache General Medicine medicine.disease Meta-analysis Migraine 030220 oncology & carcinogenesis Relative risk Anticonvulsants 030211 gastroenterology & hepatology business lcsh:Medicine (General) medicine.drug |
| Zdroj: | Journal of the Formosan Medical Association, Vol 120, Iss 1, Pp 755-764 (2021) |
| ISSN: | 0929-6646 |
| Popis: | Background Migraine is characterized by moderate to severe recurrent headache lasting for 4–72 h. Cortical hyperexcitability may play a crucial role in migraine onset. Therefore, antiepileptic drugs, such as levetiracetam, may be beneficial. Methods We performed a systematic review and meta-analysis of randomized controlled trials (RCTs) and prospective studies that evaluated the efficacy of levetiracetam in migraine prophylaxis. Electronic databases, including PubMed, EMBASE, and the Cochrane Central Register of Controlled Trials, were searched for articles on migraine prophylaxis and levetiracetam published before May 2020. The main outcomes were number of patients with >50% headache frequency reduction, frequency of headache, and headache severity. Results We identified 4 RCTs involving 192 patients and 4 prospective studies involving 85 patients. The overall data on number of patients with >50% headache frequency reduction, headache frequency, and headache severity were subjected to meta-analysis, which revealed significant differences between the levetiracetam and the placebo groups (risk ratio [RR] of number of patients with >50% headache frequency reduction = 0.46, 95% confidence interval [CI] = 0.35 to 0.61; weighted mean difference [WMD] of headache frequency per month = −3.78, 95% CI = −5.52 to −2.03; standard mean difference [SMD] of headache severity = −2.42, 95% CI = −4.47 to −0.37). Conclusion Our study indicated that levetiracetam can significantly reduce headache frequency and severity in adults and children. Thus, oral levetiracetam can be a therapeutic option for migraine prophylaxis, especially concerning with the adverse effects or teratogenicity of other preventive treatments. |
| Databáze: | OpenAIRE |
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