Dcf1 Affects Memory and Anxiety by Regulating NMDA and AMPA Receptors
| Autor: | Qiang Liu, Tieqiao Wen, Fang-Fang Ma, Yajiang Wang, Fushuai Wang, Jiayang Xie, Ruili Feng, Shiyi Shen |
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| Rok vydání: | 2019 |
| Předmět: |
Male
0301 basic medicine N-Methylaspartate Dendritic spine Dendritic Spines Hippocampus Nerve Tissue Proteins Water maze AMPA receptor Anxiety Hippocampal formation Biology Receptors N-Methyl-D-Aspartate Biochemistry Gene Knockout Techniques 03 medical and health sciences Cellular and Molecular Neuroscience 0302 clinical medicine Memory Animals Receptors AMPA Mice Knockout Neuronal Plasticity Membrane Proteins Long-term potentiation General Medicine Mice Inbred C57BL 030104 developmental biology nervous system Synapses Synaptic plasticity NMDA receptor Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Neurochemical Research. 44:2499-2505 |
| ISSN: | 1573-6903 0364-3190 |
| DOI: | 10.1007/s11064-019-02866-6 |
| Popis: | The hippocampus is critical for memory and emotion and both N-methyl-D-aspartate (NMDA) and α-amino-3-hydroxy-5-methyl- 4-isoxazolepropionic acid (AMPA) receptors are known to contribute for those processes. However, the underlying molecular mechanisms remain poorly understood. We have previously found that mice undergo memory decline upon dcf1 deletion through ES gene knockout. In the present study, a nervous system-specific dcf1 knockout (NKO) mouse was constructed, which was found to present severely damaged neuronal morphology. The damaged neurons caused structural abnormalities in dendritic spines and decreased synaptic density. Decreases in hippocampal NMDA and AMPA receptors of NKO mice lead to abnormal long term potentiation (LTP) at DG, with significantly decreased performance in the water maze, elevated- plus maze, open field and light and dark test. Investigation into the underlying molecular mechanisms revealed that dendritic cell factor 1 (Dcf1) contributes for memory and emotion by regulating NMDA and AMPA receptors. Our results broaden the understanding of synaptic plasticity's role in cognitive function, thereby expanding its known list of functions. |
| Databáze: | OpenAIRE |
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