Relationships between clinical measures of visual function and anatomic changes associated with bevacizumab treatment for choroidal neovascularization in age-related macular degeneration

Autor: Peter Presti, Stephen H. Sinclair, G A Yavuz, N. Bekiroglu, Weiye Li, Y B Ünver
Přispěvatelé: Uenver, Y. B., Yavuz, G. A., Bekiroglu, N., Presti, P., Li, W., Sinclair, S. H.
Rok vydání: 2008
Předmět:
Male
OPTICAL COHERENCE TOMOGRAPHY
genetic structures
Anticorps monoclonal
Eye disease
Visual Acuity
Angiogenesis Inhibitors
Retinal Pigment Epithelium
AVASTIN
Macular Degeneration
PHOTODYNAMIC THERAPY
central field acuity testing
Medicine
skin and connective tissue diseases
Aged
80 and over
SECONDARY
Antibodies
Monoclonal
Middle Aged
Treatment Outcome
Choroidal neovascularization
Visual function
vision outcome
INTRAVITREAL BEVACIZUMAB
Female
medicine.symptom
Tomography
Optical Coherence
medicine.drug
Retinopathy
medicine.medical_specialty
Bevacizumab
bevacizumab
Antibodies
Monoclonal
Humanized
Drug Administration Schedule
FIXATION PATTERNS
Ophthalmology
Age related
Humans
EYES
CENTRAL SCOTOMAS
age-related macular degeneration
ACUITY
Aged
business.industry
anatomic outcome
Macular degeneration
medicine.disease
Fibrosis
Choroidal Neovascularization
eye diseases
avastin treatment
Visual Field Tests
sense organs
Epidemiologic Methods
business
Zdroj: Eye. 23:453-460
ISSN: 1476-5454
0950-222X
Popis: WOS: 000263321000035 PubMed: 19039333 Purpose This pilot study was undertaken to examine the relationships between clinical measures of visual function and anatomic changes occurring in the eyes treated with bevacizumab for choroidal neovascularization (CNV) due to age-related macular degeneration (AMD). Methods A retrospective review was conducted for 50 eyes that had been treated with at least three injections of bevicizumab for CNV due to AMD, and followed for at least 6 months. Vision outcomes included best-corrected ETDRS chart acuity, scored by best-line read (ETDRS line) and by total letters read (ETDRS letter), and two measures obtained from central acuity perimetry with 98% Michelson contrast targets, the best acuity within 6 degrees of fixation (BA6 degrees), and global macular acuity (GMA), representing a weighted average of the acuities thresholded at all intercepts within a 10 degrees radius of fixation. Assessment of anatomic outcomes included fibrosis, atrophy, and subretinal hemorrhage grading on fundus photography, CNV size, pigment epithelial detachment (PED) size and grading of CNV leakage on fluorescein angiography, and central retinal PED, and subretinal fluid (SRF) thickness on optical coherence tomography. Results Logistic regression analysis showed an association between the vision outcomes of EDTRS letter and BA6 degrees with the change in SRF thickness (R-2: 0.47 and 0.35, respectively). The outcome of the vision measurement of GMA was associated with the change in SRF thickness, in CNV thickness, and in CNV fibrosis grade (R-2: 0.34). No association was noted between the outcomes of ETDRS line with the change in any anatomic outcomes. Conclusion Acuity perimetry outcomes in this study seemed to offer improved understanding of the relationship between the vision outcomes and the measured anatomic changes. It seemed that neither ocular coherence tomography nor fluorescein angiography alone offered sufficient morphologic markers for prediction of functional outcomes. TUBITAKTurkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) This study was supported by TUBITAK.
Databáze: OpenAIRE
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