The second nationwide surveillance of the antimicrobial susceptibility of Neisseria gonorrhoeae from male urethritis in Japan, 2012-2013
| Autor: | Takahide Hosobe, Shinichi Minamitani, Toru Sumii, Mitsuru Yasuda, Satoshi Iwata, Takamasa Yamaguchi, Hirofumi Nishimura, Hitoshi Kadena, Takeshi Shirane, Tetsuro Matsumoto, Shinichi Kaji, Shin Ito, Keisuke Sunakawa, Kanao Kobayashi, Seiji Naito, Hiromi Kumon, Masaru Yoshioka, Akio Matsubara, Masayasu Ito, Hiroshi Kiyota, Ryoichi Hamasuna, Shohei Nishi, Motoshi Kawahara, Shin Egawa, Shingo Yamamoto, Mutsumasa Yoh, Hirofumi Chokyu, Koichi Monden, Hideo Hirayama, Kazuo Takayama, Taiji Tsukamoto, Hideaki Hanaki, Harunori Narita, Masaru Matsumura, Satoshi Takahashi, Jun-ichi Kadota, Satoshi Uno, Kazushi Tanaka, Shinya Uehara, Junko Sato, Masato Fujisawa, Kiyohito Ishikawa, Mitsuo Kaku, Kikuo Akiyama, Kentaro Kuroiwa, Toshio Imai, Akira Watanabe, Motonori Kano, Kenji Ito, Shin-ichi Maeda, Shuichi Kawai, Hiroshi Hayami, Soichi Arakawa |
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| Rok vydání: | 2014 |
| Předmět: |
Microbiology (medical)
Sitafloxacin Adult Male Adolescent Microbial Sensitivity Tests Penicillins Azithromycin medicine.disease_cause Microbiology Tosufloxacin Young Adult Japan Levofloxacin Cefixime Drug Resistance Bacterial medicine Humans Pharmacology (medical) Urethritis Aged business.industry Ceftriaxone Middle Aged Antimicrobial medicine.disease Neisseria gonorrhoeae Anti-Bacterial Agents Ciprofloxacin Infectious Diseases Population Surveillance business medicine.drug Fluoroquinolones |
| Zdroj: | Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy. 21(5) |
| ISSN: | 1437-7780 |
| Popis: | Worldwide, the most important concern in the treatment of sexually transmitted infections is the increase in antimicrobial resistant Neisseria gonorrhoeae strains including resistance to cephalosporins, penicillins, fluoroquinolones or macrolides. To investigate the trends of antimicrobial susceptibility among N. gonorrhoeae strains isolated from male patients with urethritis, a Japanese surveillance committee conducted the second nationwide surveillance study. Urethral discharge was collected from male patients with urethritis at 26 medical facilities from March 2012 to January 2013. Of the 151 specimens, 103 N. gonorrhoeae strains were tested for susceptibility to 20 antimicrobial agents. None of the strains was resistant to ceftriaxone, but the minimum inhibitory concentration (MIC) 90% of ceftriaxone increased to 0.125 μg/ml, and 11 (10.7%) strains were considered less susceptible with an MIC of 0.125 μg/ml. There were 11 strains resistant to cefixime, and the MICs of these strains were 0.5 μg/ml. The distributions of the MICs of fluoroquinolones, such as ciprofloxacin, levofloxacin and tosufloxacin, were bimodal. Sitafloxacin, a fluoroquinolone, showed strong activity against all strains, including strains resistant to other three fluoroquinolones, such as ciprofloxacin, levofloxacin and tosufloxacin. The azithromycin MICs in 2 strains were 1 μg/ml. |
| Databáze: | OpenAIRE |
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