Acerola (Malpighia emarginata DC.) juice intake protects against alterations to proteins involved in inflammatory and lipolysis pathways in the adipose tissue of obese mice fed a cafeteria diet
| Autor: | Francine Daumann, Schérolin de Oliveira Marques, Daniela Dimer Leffa, Bruno Rodrigues, Rodrigo X. Neves, Cláudio T. De Souza, Aline Alves de Santana, Fernando Milanez Dias, Vanessa Moraes de Andrade, Lila Missae Oyama, Jonathan Correa Possato, Thais F. Luciano, José César Rosa, Fábio Santos Lira |
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| Přispěvatelé: | Univ Extremo Sul Catarinense, Universidade Federal de São Paulo (UNIFESP), Universidade de São Paulo (USP), Univ Sao Judas Tadeu, Universidade Estadual Paulista (Unesp) |
| Jazyk: | angličtina |
| Předmět: |
Male
Lipolysis Endocrinology Diabetes and Metabolism Clinical Biochemistry Anti-Inflammatory Agents Drug Evaluation Preclinical Administration Oral Mice Obese Adipokine Adipose tissue Cafeteria Ascorbic Acid Intra-Abdominal Fat Mice Endocrinology METABOLISMO ANIMAL parasitic diseases medicine Animals Humans Obesity Food science Epididymis Inflammation Biochemistry medical biology Vitamin C Plant Extracts Research Biochemistry (medical) biology.organism_classification Ascorbic acid Diet Fruit Malpighia emarginata DC Cytokines Cafeteria diet Inflammation Mediators medicine.symptom Energy Intake Weight gain Malpighiaceae Lipidology |
| Zdroj: | Web of Science Repositório Institucional da UNESP Universidade Estadual Paulista (UNESP) instacron:UNESP Lipids in Health and Disease Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual) Universidade de São Paulo (USP) instacron:USP |
| ISSN: | 1476-511X |
| DOI: | 10.1186/1476-511x-13-24 |
| Popis: | Made available in DSpace on 2014-12-03T13:11:39Z (GMT). No. of bitstreams: 0 Previous issue date: 2014-02-04Bitstream added on 2014-12-03T13:22:31Z : No. of bitstreams: 1 WOS000333647100001.pdf: 977800 bytes, checksum: ad02b6a673a9bd0447b097fd37ea1a29 (MD5) Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) Background: Obesity has been studied as a metabolic and an inflammatory disease and is characterized by increases in the production of pro-inflammatory adipokines in the adipose tissue. To elucidate the effects of natural dietary components on the inflammatory and metabolic consequences of obesity, we examined the effects of unripe, ripe and industrial acerola juice (Malpighia emarginata DC.) on the relevant inflammatory and lipolysis proteins in the adipose tissue of mice with cafeteria diet-induced obesity.Materials/methods: Two groups of male Swiss mice were fed on a standard diet (STA) or a cafeteria diet (CAF) for 13 weeks. Afterwards, the CAF-fed animals were divided into five subgroups, each of which received a different supplement for one further month (water, unripe acerola juice, ripe acerola juice, industrial acerola juice, or vitamin C) by gavage. Enzyme-linked immunosorbent assays, Western blotting, a colorimetric method and histology were utilized to assess the observed data.Results: The CAF water (control obese) group showed a significant increase in their adiposity indices and triacylglycerol levels, in addition to a reduced IL-10/TNF-alpha ratio in the adipose tissue, compared with the control lean group. In contrast, acerola juice and Vitamin C intake ameliorated the weight gain, reducing the TAG levels and increasing the IL-10/TNF-alpha ratio in adipose tissue. In addition, acerola juice intake led to reductions both in the level of phosphorylated JNK and to increases in the phosphorylation of I kappa B alpha and HSLser660 in adipose tissue.Conclusions: Taken together, these results suggest that acerola juice reduces low-grade inflammation and ameliorates obesity-associated defects in the lipolytic processes. Univ Extremo Sul Catarinense, Lab Mol & Cellular Biol, Grad Programme Hlth Sci, Dept Hlth Sci,UNESC, BR-88806000 Criciuma, SC, Brazil Univ Extremo Sul Catarinense, Lab Exercise Biochem & Physiol, Grad Programme Hlth Sci, Dept Hlth Sci,UNESC, BR-88806000 Criciuma, SC, Brazil Univ Fed Sao Paulo UNIFESP, Dept Fisiol, Disciplina Fisiol Nutr, BR-04023060 Sao Paulo, Brazil Univ Sao Paulo, Canc Metab Res Grp, Inst Biomed Sci, Sao Paulo, Brazil Univ Sao Paulo, Immunometab Res Grp, Inst Biomed Sci, Sao Paulo, Brazil Univ Sao Judas Tadeu, Lab Movimento Humano, Sao Paulo, Brazil Univ Estadual Paulista, UNESP, Immunometab Res Grp, Dept Phys Educ, BR-19060900 Presidente Prudente, SP, Brazil Univ Estadual Paulista, UNESP, Immunometab Res Grp, Dept Phys Educ, BR-19060900 Presidente Prudente, SP, Brazil |
| Databáze: | OpenAIRE |
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