Alcohol and the Brain: Neuronal Molecular Targets, Synapses, and Circuits
| Autor: | David M. Lovinger, Armando G. Salinas, Karina Possa Abrahao |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Drug medicine.medical_treatment media_common.quotation_subject Alcohol Article 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Animals Humans Medicine media_common Neurons Neuronal Plasticity Ethanol business.industry General Neuroscience Addiction Brain Ethanol exposure Stimulant Alcoholism Brain region 030104 developmental biology chemistry Synaptic plasticity Molecular targets Nerve Net business Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Neuron. 96:1223-1238 |
| ISSN: | 0896-6273 |
| DOI: | 10.1016/j.neuron.2017.10.032 |
| Popis: | Ethanol is one of the most commonly abused drugs. Although environmental and genetic factors contribute to the etiology of alcohol use disorders, it is ethanol’s actions in the brain that explain (1) acute ethanol-related behavioral changes, such as stimulant followed by depressant effects, and (2) chronic changes in behavior, including escalated use, tolerance, compulsive seeking, and dependence. Our knowledge of ethanol use and abuse thus relies on understanding its effects on the brain. Scientists have employed both bottom-up and top-down approaches, building from molecular targets to behavioral analyses and vice versa, respectively. This review highlights current progress in the field, focusing on recent and emerging molecular, cellular, and circuit effects of the drug that impact ethanol-related behaviors. The focus of the field is now on pinpointing which molecular effects in specific neurons within a brain region contribute to behavioral changes across the course of acute and chronic ethanol exposure. |
| Databáze: | OpenAIRE |
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