No association of vitamin D metabolism-related polymorphisms and melanoma risk as well as melanoma prognosis: a case–control study

Autor: Steffen Schubert, Inke R. König, Mladen V. Tzvetkov, Rotraut Mössner, Kristian Reich, Annika Schäfer, Steffen Emmert, Claudia Pföhler, Thomas Vogt, Michael P. Schön, Jörg Reichrath, Jochen Kruppa, Matthias Volkenandt, Carola Berking
Rok vydání: 2012
Předmět:
Male
Oncology
Skin Neoplasms
1
25-dihydroxyvitamin D-24-hydroxylase (CYP24A1)
Vitamin D-binding protein
Skin Pigmentation
Vitamin D3 24-Hydroxylase
Calcitriol receptor
0302 clinical medicine
Vitamin D
Melanoma
0303 health sciences
Eye Color
Vitamin D-Binding Protein
Gene polymorphism
General Medicine
Prognosis
3. Good health
030220 oncology & carcinogenesis
Female
Risk
medicine.medical_specialty
Genotype
Vitamin D receptor (VDR)
25-hydroxyvitamin D-1α-hydroxylase (CYP27B1)
Vitamin D binding protein (VDBP)
Single-nucleotide polymorphism
Dermatology
Biology
Polymorphism
Single Nucleotide
03 medical and health sciences
Internal medicine
medicine
Vitamin D and neurology
Humans
Genetic Predisposition to Disease
Hair Color
Nevus
Cell Proliferation
030304 developmental biology
25-Hydroxyvitamin D3 1-alpha-Hydroxylase
Original Paper
Medicine & Public Health
Case-control study
medicine.disease
Case-Control Studies
Steroid Hydroxylases
Immunology
Cutaneous melanoma
Receptors
Calcitriol
Zdroj: Archives of Dermatological Research
ISSN: 1432-069X
0340-3696
Popis: Melanoma is one of the most aggressive human cancers. The vitamin D system contributes to the pathogenesis and prognosis of malignancies including cutaneous melanoma. An expression of the vitamin D receptor (VDR) and an anti-proliferative effect of vitamin D in melanocytes and melanoma cells have been shown in vitro. Studies examining associations of polymorphisms in genes coding for vitamin D metabolism-related proteins (1α-hydroxylase [CYP27B1], 1,25(OH)2D-24hydroxylase [CYP24A1], vitamin D-binding protein [VDBP]) and cancer risk are scarce, especially with respect to melanoma. Mainly VDR polymorphisms regarding melanoma risk and prognosis were examined although other vitamin D metabolism-related genes may also be crucial. In our hospital-based case–control study including 305 melanoma patients and 370 healthy controls single nucleotide polymorphisms in the genes CYP27B1 (rs4646536), CYP24A1 (rs927650), VDBP (rs1155563, rs7041), and VDR (rs757343, rs731236, rs2107301, rs7975232) were analyzed for their association with melanoma risk and prognosis. Except VDR rs731236 and VDR rs2107301, the other six polymorphisms have not been analyzed regarding melanoma before. To further improve the prevention as well as the treatment of melanoma, it is important to identify further genetic markers for melanoma risk as well as prognosis in addition to the crude phenotypic, demographic, and environmental markers used in the clinic today. A panel of genetic risk markers could help to better identify individuals at risk for melanoma development or worse prognosis. We, however, found that none of the polymorphisms tested was associated with melanoma risk as well as prognosis in logistic and linear regression models in our study population. peerReviewed
Databáze: OpenAIRE
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