Prognostic image-based quantification of CD8CD103 T cell subsets in high-grade serous ovarian cancer patients
Autor: | R. Yigit, Hagma H. Workel, S. T. Paijens, A. J. Kruse, Joost Bart, D Loiero, M. de Bruyn, Annege Vledder, N.M. de Lange, Annechien Plat, Mathilde Jalving, G. B. A. Wisman, V. H. Koelzer, H.J.G. Arts, N Werner, Harmen Hollema, Evelien W. Duiker, Hans W. Nijman, A. M. Hendriks |
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Přispěvatelé: | Targeted Gynaecologic Oncology (TARGON), Translational Immunology Groningen (TRIGR) |
Jazyk: | angličtina |
Rok vydání: | 2021 |
Předmět: |
0301 basic medicine
Oncology medicine.medical_specialty Stromal cell T cell overall survival Immunology CD8-Positive T-Lymphocytes 03 medical and health sciences Lymphocytes Tumor-Infiltrating 0302 clinical medicine Immune system T-Lymphocyte Subsets Internal medicine Serous ovarian cancer medicine Humans Immunology and Allergy digital quantification RC254-282 Original Research Ovarian Neoplasms cd8cd103 t cell business.industry Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC581-607 tissue resident memory t cells Cystadenocarcinoma Serous 030104 developmental biology medicine.anatomical_structure 030220 oncology & carcinogenesis high grade serous ovarian cancer T cell subset Immunohistochemistry Female prognosis Immunologic diseases. Allergy business Image based CD8 Research Article |
Zdroj: | OncoImmunology, Vol 10, Iss 1 (2021) Oncoimmunology article-version (VoR) Version of Record OncoImmunology, 10(1):1935104. Taylor & Francis Group |
ISSN: | 2162-4011 |
Popis: | CD103-positive tissue resident memory-like CD8+ T cells (CD8CD103 TRM) are associated with improved prognosis across malignancies, including high-grade serous ovarian cancer (HGSOC). However, whether quantification of CD8, CD103 or both is required to improve existing survival prediction and whether all HGSOC patients or only specific subgroups of patients benefit from infiltration, remains unclear. To address this question, we applied image-based quantification of CD8 and CD103 multiplex immunohistochemistry in the intratumoral and stromal compartments of 268 advanced-stage HGSOC patients from two independent clinical institutions. Infiltration of CD8CD103 immune cell subsets was independent of clinicopathological factors. Our results suggest CD8CD103 TRM quantification as a superior method for prognostication compared to single CD8 or CD103 quantification. A survival benefit of CD8CD103 TRM was observed only in patients treated with primary cytoreductive surgery. Moreover, survival benefit in this group was limited to patients with no macroscopic tumor lesions after surgery. This approach provides novel insights into prognostic stratification of HGSOC patients and may contribute to personalized treatment strategies in the future. |
Databáze: | OpenAIRE |
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