Prognostic image-based quantification of CD8CD103 T cell subsets in high-grade serous ovarian cancer patients

Autor: R. Yigit, Hagma H. Workel, S. T. Paijens, A. J. Kruse, Joost Bart, D Loiero, M. de Bruyn, Annege Vledder, N.M. de Lange, Annechien Plat, Mathilde Jalving, G. B. A. Wisman, V. H. Koelzer, H.J.G. Arts, N Werner, Harmen Hollema, Evelien W. Duiker, Hans W. Nijman, A. M. Hendriks
Přispěvatelé: Targeted Gynaecologic Oncology (TARGON), Translational Immunology Groningen (TRIGR)
Jazyk: angličtina
Rok vydání: 2021
Předmět:
0301 basic medicine
Oncology
medicine.medical_specialty
Stromal cell
T cell
overall survival
Immunology
CD8-Positive T-Lymphocytes
03 medical and health sciences
Lymphocytes
Tumor-Infiltrating
0302 clinical medicine
Immune system
T-Lymphocyte Subsets
Internal medicine
Serous ovarian cancer
medicine
Humans
Immunology and Allergy
digital quantification
RC254-282
Original Research
Ovarian Neoplasms
cd8cd103 t cell
business.industry
Neoplasms. Tumors. Oncology. Including cancer and carcinogens
RC581-607
tissue resident memory t cells
Cystadenocarcinoma
Serous
030104 developmental biology
medicine.anatomical_structure
030220 oncology & carcinogenesis
high grade serous ovarian cancer
T cell subset
Immunohistochemistry
Female
prognosis
Immunologic diseases. Allergy
business
Image based
CD8
Research Article
Zdroj: OncoImmunology, Vol 10, Iss 1 (2021)
Oncoimmunology
article-version (VoR) Version of Record
OncoImmunology, 10(1):1935104. Taylor & Francis Group
ISSN: 2162-4011
Popis: CD103-positive tissue resident memory-like CD8+ T cells (CD8CD103 TRM) are associated with improved prognosis across malignancies, including high-grade serous ovarian cancer (HGSOC). However, whether quantification of CD8, CD103 or both is required to improve existing survival prediction and whether all HGSOC patients or only specific subgroups of patients benefit from infiltration, remains unclear. To address this question, we applied image-based quantification of CD8 and CD103 multiplex immunohistochemistry in the intratumoral and stromal compartments of 268 advanced-stage HGSOC patients from two independent clinical institutions. Infiltration of CD8CD103 immune cell subsets was independent of clinicopathological factors. Our results suggest CD8CD103 TRM quantification as a superior method for prognostication compared to single CD8 or CD103 quantification. A survival benefit of CD8CD103 TRM was observed only in patients treated with primary cytoreductive surgery. Moreover, survival benefit in this group was limited to patients with no macroscopic tumor lesions after surgery. This approach provides novel insights into prognostic stratification of HGSOC patients and may contribute to personalized treatment strategies in the future.
Databáze: OpenAIRE
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