GC and VDR SNPs and Vitamin D Levels in Parkinson's Disease: The Relevance to Clinical Features

Autor: Duygu Gezen-Ak, Hasmet Hanagasi, Irem L. Atasoy, Selma Yilmazer, Başar Bilgiç, Esin Candaş, Hakan Gurvit, Aysegul Gunduz, Hulya Apaydin, Sibel Ertan, Erdinç Dursun, Güneş Kızıltan, Gençer Genç, Merve Alaylıoğlu
Rok vydání: 2016
Předmět:
0301 basic medicine
Male
Turkey
Vitamin D-binding protein
Calcitriol receptor
Antiparkinson Agents
Levodopa
chemistry.chemical_compound
0302 clinical medicine
Age of Onset
Aged
80 and over
Vitamin D-Binding Protein
Parkinson Disease
Middle Aged
FokI
Neurology
Molecular Medicine
Female
Polymorphism
Restriction Fragment Length
Adult
Risk
medicine.medical_specialty
Genotype
Single-nucleotide polymorphism
Biology
Polymorphism
Single Nucleotide
vitamin D deficiency
03 medical and health sciences
Cellular and Molecular Neuroscience
Young Adult
Internal medicine
medicine
Vitamin D and neurology
Humans
Genetic Predisposition to Disease
RNA
Messenger
Alleles
Aged
Calcifediol
medicine.disease
Minor allele frequency
030104 developmental biology
Endocrinology
chemistry
Haplotypes
Case-Control Studies
Immunology
Luminescent Measurements
biology.protein
Receptors
Calcitriol
030217 neurology & neurosurgery
Zdroj: Neuromolecular medicine. 19(1)
ISSN: 1559-1174
Popis: Vitamin D deficiency is suggested to be associated with Parkinson's disease (PD). Our aim was to investigate the serum 25-hydroxyvitamin D3 (25OHD) levels of PD patients in Turkish cohort, to investigate any association of vitamin D binding protein (GC) genotypes with PD due to the significant role of GC in vitamin D transport, to determine whether vitamin D receptor (VDR) haplotype that we previously demonstrated to be a risk haplotype for AD is also a common haplotype for PD and to investigate any relevant consequence of serum 25OHD levels, GC or VDR genotypes on clinical features of PD. Three hundred eighty-two PD patients and 242 healthy subjects were included in this study. The serum 25OHD levels were investigated by CLIA, and GC and VDR SNPs were evaluated with LightSnip. Our results indicated a strong relationship between low serum 25OHD levels and PD (p
Databáze: OpenAIRE
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