Systematic Influence of Circulating Bilirubin Levels on Osteoporosis
| Autor: | Zhengxue Quan, Jinqiu Zhao, Bin He, Liang Deng, Muzi Zhang, Yongguo Li |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Adult
Male medicine.medical_specialty Endocrinology Diabetes and Metabolism Osteoporosis Genome-wide association study Polymorphism Single Nucleotide Gastroenterology Diseases of the endocrine glands. Clinical endocrinology Fractures Bone Endocrinology Bone Density Risk Factors BMD Internal medicine Mendelian randomization medicine Humans Mendelian randomization study Risk factor Aged Original Research Aged 80 and over Bone mineral business.industry Incidence (epidemiology) Bilirubin Mendelian Randomization Analysis Middle Aged RC648-665 medicine.disease osteoporosis Confidence interval Causality fracture Female Observational study business circulating bilirubin levels Genome-Wide Association Study |
| Zdroj: | Frontiers in Endocrinology, Vol 12 (2021) Frontiers in Endocrinology |
| ISSN: | 1664-2392 |
| DOI: | 10.3389/fendo.2021.719920 |
| Popis: | Observational studies report some association between circulating bilirubin levels and osteoporosis, but it is unknown if this association is causal or confounded. In this two-sample Mendelian randomization (MR) study, we included a large genome-wide association study (GWAS) associated with total bilirubin levels among 317,639 people, a large meta-analysis to identify genetic variants associated with bone mineral density (BMD) estimated by heel quantitative ultrasound (eBMD) among 426,824 individuals and fracture among 1.2 million individuals. The results revealed that circulating bilirubin levels had no causal influence on eBMD (beta-estimate: 0.004, 95% confidence interval [CI]: -0.019 to 0.028, SE:0.012, P-value=0.705) or the risk of fracture (beta-estimate: -0.009, 95% CI: -0.035 to 0.017, SE:0.013, P-value=0.488), which were both confirmed by multiple sensitivity analyses. Our results confirm that circulating bilirubin levels have no causal role in eBMD or the incidence of fracture, indicating that circulating bilirubin levels is unlikely to be a causal risk factor for osteoporosis or fracture. |
| Databáze: | OpenAIRE |
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