Leucemia de células plasmáticas primaria: experiencia en un hospital público chileno
| Autor: | Maria Eugenia Legues, María Soledad Undurraga, Maria Elena Cabrera, Macarena Roa, María Gabriela Mendoza, Rocío Osorio, Margarita Reyes, Camila Peña, Ximena Valladares |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
CD20
Plasma cell leukemia medicine.medical_specialty Hematology biology business.industry Paraproteinemias General Medicine medicine.disease Gastroenterology Leukemia Plasma Cell Leukemia medicine.anatomical_structure White blood cell Internal medicine Monoclonal biology.protein Medicine Bortezamib business Survival analysis Multiple myeloma |
| Zdroj: | Revista médica de Chile v.147 n.1 2019 SciELO Chile CONICYT Chile instacron:CONICYT |
| ISSN: | 0034-9887 |
| Popis: | Background: Primary plasma cell leukemia (pPCL) is uncommon, aggressive and has a different biology than multiple myeloma (MM). Aim: To report the features of patients with pPCL. Material and Methods: Review of databases of the Hematology Department and the Hematology laboratory. Results: Of 178 patients with monoclonal gammopathies, five (2.8%) patients aged 33 to 64 years (three females) had a pPCL. The mean hemoglobin was 7.3 g/dL, the mean white blood cell count was 52,500/mm3, with 58% plasma cells, and the mean platelet count was 83,600/mm3. The mean bone marrow infiltration was 89%, LDH was 2,003 IU/L, serum calcium was 13 mg/dL, and creatinine 1.5 mg/dL. Two patients had bone lesions. Three were IgG, one IgA lambda and one lambda light chain. CD20 was positive in one, CD56 was negative in all and CD117 was negative in 3 cases. By conventional cytogenetic analysis, two had a complex karyotype. By Fluorescence in situ Hybridization, one was positive for TP53 and another for t (11; 14). One patient did not receive any treatment, three patients received VTD PACE and one CTD. None underwent transplant. Three patients are alive. The mean survival was 14 months. Conclusions: These patients with pPCL were younger and had a more aggressive clinical outcome than in multiple myeloma. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|