Neutrophil function is impaired in paediatric patients with malignancy and may be a useful clinical marker
| Autor: | B. Pizer, Jesús Reiné, Daniela M. Ferreira, C. Thorbinson, A. Sewell, K. Cooper, J. Lyall, Ben Morton, E Hincks |
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| Rok vydání: | 2020 |
| Předmět: |
Male
0301 basic medicine Cancer Research medicine.medical_specialty Adolescent Neutrophils medicine.medical_treatment Disease Neutropenia Malignancy Sepsis 03 medical and health sciences 0302 clinical medicine Phagocytosis Neoplasms Internal medicine medicine Humans Prospective Studies Child Prospective cohort study Whole blood Chemotherapy business.industry Infant Newborn Infant General Medicine medicine.disease 3. Good health 030104 developmental biology Oncology Child Preschool 030220 oncology & carcinogenesis Biomarker (medicine) Female business Biomarkers |
| Zdroj: | Clinical and Translational Oncology. 22:2121-2125 |
| ISSN: | 1699-3055 1699-048X |
| DOI: | 10.1007/s12094-020-02362-2 |
| Popis: | Patients treated with cytotoxic chemotherapy are at risk of neutropenia, neutropenic fever and neutropenic sepsis. We hypothesised that pre-existing neutrophil function dysfunction may increase susceptibility to neutropenic fever in paediatric patients receiving cytotoxic chemotherapy. Prospective cohort study recruited patients at Alder Hey Children’s NHS Foundation Trust, United Kingdom. We measured neutrophil phagocytic function using a validated flow cytometric whole blood phagocytosis assay in paediatric patients (n = 16) with oncological disease before and after chemotherapy in a prospective cohort study. We recruited healthy children as a control comparator (n = 10). We found significantly decreased phagocytic function in oncology patients compared to healthy participants. In five patients who developed neutropenic fever, we observed increased pre-dose neutrophil respiratory burst. With further validation, measurement of neutrophil function could potentially be used to personalise appropriate prophylactic antimicrobial administration for patients receiving cytotoxic chemotherapy. |
| Databáze: | OpenAIRE |
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