Quality Control of Danggui Buxue Tang, a Traditional Chinese Medicine Decoction, by H-NMR Metabolic Profiling
| Autor: | Chi Yuen Cheung, Henry H N Lam, Karl Wah Keung Tsim, Wendy L. Zhang, Pui Hei Chan |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
Angelica sinensis
Danggui Buxue Tang biology Traditional medicine Article Subject business.industry Decoction lcsh:Other systems of medicine Traditional Chinese medicine lcsh:RZ201-999 biology.organism_classification Complementary and alternative medicine Proton NMR Medicine business Metabolic profile |
| Zdroj: | Evidence-Based Complementary and Alternative Medicine, Vol 2014 (2014) |
| ISSN: | 1741-427X |
| DOI: | 10.1155/2014/567893 |
| Popis: | Danggui Buxue Tang (DBT) is one of the simplest traditional Chinese medicine (TCM) decoctions, first described in China in 1247 AD. DBT is composed of 2 herbs, Astragali Radix (AR) and Angelica Sinensis Radix (ASR), boiled together in a 5 : 1 ratio. Clinically, DBT is prescribed to women as a remedy for menopausal symptoms. Here,H-NMR metabolic profiling was conducted for DBT and the water extracts of AR or ASR, to evaluate the potential of this chemical profiling method for quality control of the herbal decoction. Principal component analysis (PCA) showed that DBT could be readily distinguished from the water extracts of its constituent herbs by the metabolic profiles. More interestingly, the metabolic profile of DBT was not a simple sum of that of AR and ASR. Asparagine was found at significantly higher concentration in DBT than that in either AR or ASR extract, contributing mainly to the discrimination of DBT sample. In addition, we employed the same method to profile a commercial DBT powder, verifying its authenticity as compared to our prepared DBT. This study is the first to employH-NMR metabolic profiling for the quality control of traditional Chinese medicine decoctions. |
| Databáze: | OpenAIRE |
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