Clinical perspectives of PSMA PET/MRI for prostate cancer
| Autor: | Felipe de Galiza Barbosa, Giovanni Guido Cerri, Marcelo Queiroz, José Flávio Gomes Marin, Carlos Alberto Buchpiguel, Rafael F. Nunes |
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| Rok vydání: | 2018 |
| Předmět: |
Glutamate Carboxypeptidase II
Male Diagnostic Imaging Biochemical recurrence Biodistribution Tumor Staging urologic and male genital diseases 030218 nuclear medicine & medical imaging BIOMARCADORES 03 medical and health sciences Prostate cancer 0302 clinical medicine Positron Emission Tomography Computed Tomography Glutamate carboxypeptidase II Medical imaging Humans Medicine Local Neoplasm Recurrence Positron emission tomography–magnetic resonance imaging lcsh:R5-920 medicine.diagnostic_test business.industry Prostate Cancer Prostatic Neoplasms Magnetic resonance imaging General Medicine Prostate-Specific Antigen medicine.disease Magnetic Resonance Imaging Positron emission tomography 030220 oncology & carcinogenesis Antigens Surface Positron Emission Tomography/Magnetic Resonance Imaging Neoplasm Recurrence Local lcsh:Medicine (General) business Nuclear medicine |
| Zdroj: | Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual) Universidade de São Paulo (USP) instacron:USP Clinics, Volume: 73 Supplement 1, Article number: e586s, Published: 21 SEP 2018 Clinics; v. 73 n. Suppl. 1 (2018); e586s Clinics; Vol. 73 Núm. Suppl. 1 (2018); e586s Clinics; Vol. 73 No. Suppl. 1 (2018); e586s Clinics Clinics, Vol 73, Iss suppl 1 (2018) |
| ISSN: | 1980-5322 1807-5932 |
| Popis: | Prostate cancer imaging has become an important diagnostic modality for tumor evaluation. Prostate-specific membrane antigen (PSMA) positron emission tomography (PET) has been extensively studied, and the results are robust and promising. The advent of the PET/magnetic resonance imaging (MRI) has added morphofunctional information from the standard of reference MRI to highly accurate molecular information from PET. Different PSMA ligands have been used for this purpose including 68gallium and 18fluorine-labeled PET probes, which have particular features including spatial resolution, imaging quality and tracer biodistribution. The use of PSMA PET imaging is well established for evaluating biochemical recurrence, even at low prostate-specific antigen (PSA) levels, but has also shown interesting applications for tumor detection, primary staging, assessment of therapeutic responses and treatment planning. This review will outline the potential role of PSMA PET/MRI for the clinical assessment of PCa. |
| Databáze: | OpenAIRE |
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