Bioactive constituents from Vitex negundo var. heterophylla and their antioxidant and α-glucosidase inhibitory activities
| Autor: | Hui-Ming Hua, Ping Hu, Quan Liu, Dahong Li, Xiao-Fei Wang, Cui-Cui Jia, Zhan-Lin Li |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Iridoid Glycosides
Antioxidant Vitex negundo DPPH medicine.medical_treatment α-Glucosidase inhibitory activity Medicine (miscellaneous) Coumarin 01 natural sciences chemistry.chemical_compound Antioxidant activity Iridoid glycoside Botany medicine TX341-641 chemistry.chemical_classification Nutrition and Dietetics ABTS biology Traditional medicine Nutrition. Foods and food supply 010405 organic chemistry Chemistry Vitex negundo var. heterophylla Glycoside biology.organism_classification Ascorbic acid 0104 chemical sciences 010404 medicinal & biomolecular chemistry Food Science |
| Zdroj: | Journal of Functional Foods, Vol 35, Iss, Pp 236-244 (2017) |
| ISSN: | 1756-4646 |
| DOI: | 10.1016/j.jff.2017.05.047 |
| Popis: | Vitex negundo L. var. heterophylla (Franch.) Rehd. is widely accepted as a functional and medicinal food in China because of the presence of bioactive components which improve the physical condition. In the present study, the bioactive constituents, antioxidant, α -glucosidase and DPP-IV inhibitory activities of V. negundo var. heterophylla were investigated. Two new coumarin glycosides, vitexnegheteroins I-J ( 1 – 2 ), and two new iridoid glycosides, vitexnegheteroins K-L ( 3 – 4 ), were isolated from the leaves and seeds of V. negundo var. heterophylla , together with twenty known compounds. Seven compounds presented stronger antioxidant activities than l -ascorbic acid in both DPPH and ABTS assays. Among them, isoorientin-6″- O -caffeate ( 22 ) also exhibited more potent α -glucosidase inhibitory activity than acarbose with an IC 50 value of 0.24 ± 0.02 μM. These findings further revealed the bioactive components of this edible aromatic plant and disclosed the potency of it to be developed as new antioxidant and α -glucosidase inhibitory agents. |
| Databáze: | OpenAIRE |
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