Aquaporin Positron Emission Tomography Differentiates Between Grade III and IV Human Astrocytoma
| Autor: | Yukihiro Nakamura, Yuji Suzuki, Tsutomu Nakada, Hiroki Kitaura, Yukihiko Fujii, Satoshi Kurabe, Kouichirou Okamoto, Vincent J. Huber, Ingrid L. Kwee, Akiyoshi Kakita, Hiroshi Aoki, Hironaka Igarashi, Kenichi Yamada |
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| Rok vydání: | 2017 |
| Předmět: |
Adult
Male Niacinamide 0301 basic medicine Pathology medicine.medical_specialty Histopathological grading [11C]TGN-020 Aquaporin Neuroimaging Astrocytoma Aquaporin1 (AQP1) Aquaporins Infiltrative Growth White matter 03 medical and health sciences 0302 clinical medicine Thiadiazoles Biomarkers Tumor medicine Radioligand Humans Aged Aged 80 and over medicine.diagnostic_test Brain Neoplasms business.industry Middle Aged medicine.disease Aquaporin4 (AQP4) Research—Human—Clinical Studies 030104 developmental biology medicine.anatomical_structure Positron emission tomography Positron-Emission Tomography Positron emission tomography (PET) Aquaporin 1 Female Surgery Neurology (clinical) Neoplasm Grading Radiopharmaceuticals business 030217 neurology & neurosurgery |
| Zdroj: | Neurosurgery |
| ISSN: | 1524-4040 0148-396X |
| Popis: | BACKGROUND Aquaporin (AQP) water channels play a significant role in mesenchymal microvascular proliferation and infiltrative growth. AQPs are highly expressed in malignant astrocytomas, and a positive correlation is observed between their expression levels and histological tumor grade. OBJECTIVE To examine the utility of aquaporin positron emission tomography (PET) for differentiating between astrocytoma grade III and grade IV using the AQP radioligand [11C]TGN-020. METHODS Fifteen astrocytoma patients, grade III (n = 7) and grade IV (n = 8), and 10 healthy volunteers underwent [11C]TGN-020 aquaporin PET imaging. Surgical tissues of astrocytoma patients were examined for histopathological grading using the WHO classification standard and expression of AQP1 and AQP4 immunohistochemically. RESULTS Mean standardized uptake values of astrocytoma grade III and IV (0.51 ± 0.11 vs 1.50 ± 0.44, respectively) were higher than normal white matter (0.17 ± 0.02, P < .001) for both tumor grades. Importantly, mean standardized uptake values of astrocytoma grade IV were significantly higher than grade III (P < .01). CONCLUSION Our study demonstrated that [11C]TGN-020 aquaporin PET imaging differentiated between astrocytoma grades III and IV. We suggest its clinical application as a noninvasive diagnostic tool would lead to advancements in the management of these malignant brain tumors. |
| Databáze: | OpenAIRE |
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