Marine fatty acids aggravate hepatotoxicity of α-HBCD in juvenile female BALB/c mice
| Autor: | Bente E. Torstensen, Lene Secher Myrmel, Marc H.G. Berntssen, Even Fjære, J.D. Rasinger, Karsten Kristiansen, Trond Brattelid, Annette Bernhard, Anita Røyneberg Alvheim, Lise Madsen, Anne-Katrine Lundebye |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Food Contamination 010501 environmental sciences Real-Time Polymerase Chain Reaction Toxicology 01 natural sciences BALB/c Mice 03 medical and health sciences chemistry.chemical_compound Internal medicine medicine Animals Oily fish RNA Messenger 0105 earth and related environmental sciences Hexabromocyclododecane chemistry.chemical_classification Mice Inbred BALB C Dose-Response Relationship Drug biology Reverse Transcriptase Polymerase Chain Reaction Fatty Acids Fatty liver Fatty acid Lipid metabolism General Medicine biology.organism_classification medicine.disease Diet Hydrocarbons Brominated 030104 developmental biology Endocrinology Gene Expression Regulation Liver Seafood chemistry Toxicity Female Food Science Polyunsaturated fatty acid |
| Zdroj: | Food and Chemical Toxicology. 97:411-423 |
| ISSN: | 0278-6915 |
| Popis: | Oily fish, a source of long-chain omega-3 polyunsaturated fatty acids (LC n-3 PUFAs), may contain persistent organic pollutants (POPs), including α-hexabromocyclododecane (α-HBCD). In experimental studies, marine LC n-3 PUFAs ameliorate fatty liver development while HBCD exposure was found to cause liver fatty acid (FA) changes. The present study investigated interactions of FAs and α-HBCD in juvenile female BALB/c mice using a factorial design. Mice (n = 48) were exposed for 28 days to a low (100 μg*kg body weight (BW) −1 *day −1 ) or high dose (100 mg*kg BW −1 *day −1 ) of α-HBCD in diets with or without LC n-3 PUFAs. High dose α-HBCD affected whole body lipid metabolism leading to changes in body weight and composition, and pathological changes in hepatic histology, which surprisingly were aggravated by dietary LC n-3 PUFAs. Hepatic FA profiling and gene expression analysis indicated that the dietary modulation of the hepatotoxic response to the high dose of α-HBCD was associated with differential effects on FA β-oxidation. Our results suggest that in a juvenile mouse model, marine FAs accentuate hepatotoxic effects of high dose α-HBCD. This highlights that the background diet is a critical variable in the risk assessment of POPs and warrants further investigation of dietary mediated toxicity of food contaminants. |
| Databáze: | OpenAIRE |
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