Thirty Years of sRNA-Mediated Regulation in Staphylococcus aureus: From Initial Discoveries to In Vivo Biological Implications
| Autor: | Guillaume Menard, Chloé Silard, Marie Suriray, Astrid Rouillon, Yoann Augagneur |
|---|---|
| Přispěvatelé: | CHU Pontchaillou [Rennes], ARN régulateurs bactériens et médecine (BRM), Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Inserm, University of Rennes, Jonchère, Laurent |
| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: |
Staphylococcus aureus
Organic Chemistry regulation General Medicine [SDV.MP.BAC]Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology Catalysis Computer Science Applications Inorganic Chemistry virulence sRNAs Physical and Theoretical Chemistry targetome in vivo expression [SDV.MP.BAC] Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology Molecular Biology metabolism Spectroscopy |
| Zdroj: | International Journal of Molecular Sciences International Journal of Molecular Sciences, 2022, 23 (13), pp.7346. ⟨10.3390/ijms23137346⟩ |
| ISSN: | 1661-6596 1422-0067 |
| DOI: | 10.3390/ijms23137346⟩ |
| Popis: | International audience; Staphylococcus aureus is a widespread livestock and human pathogen that colonizes diverse microenvironments within its host. Its adaptation to the environmental conditions encountered within humans relies on coordinated gene expression. This requires a sophisticated regulatory network, among which regulatory RNAs (usually called sRNAs) have emerged as key players over the last 30 years. In S. aureus, sRNAs regulate target genes at the post-transcriptional level through base-pair interactions. The functional characterization of a subset revealed that they participate in all biological processes, including virulence, metabolic adaptation, and antibiotic resistance. In this review, we report 30 years of S. aureus sRNA studies, from their discovery to the in-depth characterizations of some of them. We also discuss their actual in vivo contribution, which is still lagging behind, and their place within the complex regulatory network. These shall be key aspects to consider in order to clearly uncover their in vivo biological functions. |
| Databáze: | OpenAIRE |
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