Estudo de liberação e permeação in vitro do diclofenaco de dietilamônio em microemulsão gel-like

Autor:	Eryvaldo Sócrates Tabosa do Egito, Ana Amélia M. Lira, Valeria Ferreira da Costa Borba, Davi Pereira de Santana, José Alexsandro da Silva, Danilo Galindo César Bedor
Rok vydání:	2009
Předmět:	Chromatography diclofenac diethylamine Carrier system Chemistry Stereochemistry Diffusion in vitro release General Chemistry Permeation behavioral disciplines and activities microemulsion gel-like Diclofenac Diethylamine Microemulsion Delivery system
Zdroj:	Química Nova v.32 n.6 2009 Química Nova Sociedade Brasileira de Química (SBQ) instacron:SBQ
ISSN:	0100-4042
Popis:	The goal of this study was to produce and characterize a new microemulsion gel-like carrier system (MEG) by using the pseudo-ternary phase-diagram concept. The diclofenac diethylamine (DDA) was incorporated in the MEG and its in vitro release and permeation profiles were performed using Franz-type diffusion cells. The results revealed that the commercial DDA emulgel provided significantly higher Kp of DDA (2.2-fold) as compared to the MEG. Similar data were obtained in the permeation studies in which DDA Kp 4.7-fold higher. Therefore, MEG presents higher potential as a topical delivery system for DDA when compared to the commercial DDA emulgel.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b970f207ca074371085a2fc32b8f747 https://doi.org/10.1590/s0100-40422009000600005 Zobrazit plný text záznamu