Piperazine derivatives as iron chelators: a potential application in neurobiology
| Autor: | C. Bureau, N. T. Ha Duong, J. M. El Hage Chahine, S. Abdelsayed, Nawal Serradji, Patrick P. Michel, E. C. Hirsch |
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| Rok vydání: | 2015 |
| Předmět: |
Iron Chelating
Primary Cell Culture Iron Chelating Agents Ferric Compounds Neuroprotection Piperazines General Biochemistry Genetics and Molecular Biology Biomaterials chemistry.chemical_compound Chlorides Mesencephalon medicine Animals Organic chemistry Chelation Rats Wistar Dopaminergic Neurons Dopaminergic Metals and Alloys Spectrophotometric titration Neurotoxicity Hydrogen-Ion Concentration Embryo Mammalian medicine.disease Combinatorial chemistry Rats Kinetics Piperazine Neuroprotective Agents chemistry Thermodynamics General Agricultural and Biological Sciences |
| Zdroj: | BioMetals. 28:1043-1061 |
| ISSN: | 1572-8773 0966-0844 |
| Popis: | Polysubstituted piperazine derivatives, designed as new iron chelators, were synthesized and fully characterized by nuclear magnetic resonance and mass spectroscopy. Their potential to prevent iron-induced neurotoxicity was assessed using a cellular model of Parkinson disease. We demonstrated their ability to provide sustained neuroprotection to dopaminergic neurons that are vulnerable in this pathology. The iron chelating properties of the new compounds were determined by spectrophotometric titration illustrating that high affinity for iron is not associated with important neuroprotective effects. |
| Databáze: | OpenAIRE |
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