Effect of Age on Blood Rheology in Sickle Cell Anaemia and Sickle Cell Haemoglobin C Disease: A Cross-Sectional Study
| Autor: | Arnaud Hot, Vincent Pialoux, Sarah Skinner, Yann Lamarre, Yves Bertrand, Camille Faes, Marc Romana, Cyril Martin, Kamila Kebaili, Lydia Divialle-Doumdo, Philippe Connes, Xavier Waltz, Céline Renoux, Giovanna Cannas, Nathalie Lemonne, Marie-Dominique Hardy-Dessources, Alexandra Gauthier, Maryse Etienne-Julan, Elie Nader, Daniela Cuzzubbo, Philippe Joly, Séverine Ferdinand, Marie Petras, Nathalie Garnier |
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| Přispěvatelé: | Laboratoire Interuniversitaire de Biologie de la Motricité (LIBM ), Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet [Saint-Étienne] (UJM), Université des Antilles et de la Guyane (UAG), Observatoire Régional de la Santé de la Guadeloupe, Unité Transversale de la Drépanocytose, CHU Pointe-à-Pitre/Abymes [Guadeloupe], Amélioration génétique et adaptation des plantes méditerranéennes et tropicales (UMR AGAP), Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-Institut National de la Recherche Agronomique (INRA)-Centre international d'études supérieures en sciences agronomiques (Montpellier SupAgro)-Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro), Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro), Hôpital Edouard Herriot [CHU - HCL], Hospices Civils de Lyon (HCL), Laboratoire d'Excellence : Biogenèse et pathologies du globule rouge (Labex Gr-Ex), Université Paris Diderot - Paris 7 (UPD7)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM), Biologie Intégrée du Globule Rouge (BIGR (UMR_S_1134 / U1134)), Institut National de la Transfusion Sanguine [Paris] (INTS)-Université Paris Diderot - Paris 7 (UPD7)-Université de La Réunion (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université des Antilles (UA), Institut d’Hémato-Oncologie Pédiatrique, Service de Médecine Interne, Hospices Civils de Lyon (HCL)-Hospices Civils de Lyon (HCL), The authors have no support or funding to report., Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet [Saint-Étienne] (UJM)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry]), Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro)-Institut National de la Recherche Agronomique (INRA)-Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-Centre international d'études supérieures en sciences agronomiques (Montpellier SupAgro), Institut National de la Transfusion Sanguine [Paris] (INTS)-Université Paris Diderot - Paris 7 (UPD7)-Université de La Réunion (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pointe-à-Pitre/Abymes [Guadeloupe] -Université des Antilles (UA), CHU Pointe-à-Pitre/Abymes [Guadeloupe] -Hôpital Ricou, Laboratory of Excellence GR-Ex 'The red cell: from genesis to death', PRES Sorbonne Paris Cité, SIGNAL-IMAGE-COMMUNICATION (SIC), Université de Poitiers-Centre National de la Recherche Scientifique (CNRS), Protéines de la membrane érythrocytaire et homologues non-érythroides, Université des Antilles et de la Guyane (UAG)-Institut National de la Transfusion Sanguine [Paris] (INTS)-Université Paris Diderot - Paris 7 (UPD7)-Université de La Réunion (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM), Adaptation, Climat Tropical, Exercice et Santé (ACTES), Université des Antilles (UA), Service d'hématologie : Immuno-Hématologie pédiatrique et transplantation de moelle osseuse, Hôpital Debrousse, ROMANA, marc, Hôpital Ricou-CHU Pointe-à-Pitre/Abymes [Guadeloupe] |
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Male
Aging Blood viscosity Physiology Hematocrit MESH: Hemoglobin C/biosynthesis Physical Chemistry Erythrocyte aggregation Hydroxycarbamide MESH: Anemia Sickle Cell/blood 0302 clinical medicine MESH: Child Erythrocyte deformability Child lcsh:Science ComputingMilieux_MISCELLANEOUS MESH: Blood Viscosity Viscosity Physics Classical Mechanics [SDV.MHEP.HEM]Life Sciences [q-bio]/Human health and pathology/Hematology MESH: Infant Healthy Volunteers 3. Good health Hemoglobin C Blood Genetic Diseases MESH: Young Adult Child Preschool 030220 oncology & carcinogenesis Physical Sciences Statistics (Mathematics) Materials Science MESH: Viscosity MESH: Hematocrit 03 medical and health sciences MESH: Cross-Sectional Studies Erythrocyte Deformability Humans Statistical Methods MESH: Adolescent MESH: Age Factors MESH: Humans lcsh:R MESH: Child Preschool Biology and Life Sciences Infant MESH: Adult medicine.disease MESH: Hydroxyurea/therapeutic use Hemoglobinopathies Health Care Red blood cell Cross-Sectional Studies Hemorheology Immunology Population Groupings lcsh:Q MESH: Female Mathematics [SDV.MHEP.HEM] Life Sciences [q-bio]/Human health and pathology/Hematology Erythrocyte Aggregation MESH: Erythrocyte Deformability [SDV]Life Sciences [q-bio] lcsh:Medicine Mathematical and Statistical Techniques Materials Physics Medicine and Health Sciences Hydroxyurea MESH: Healthy Volunteers Pathology and laboratory medicine Multidisciplinary medicine.diagnostic_test MESH: Infant Newborn Age Factors Hematology Blood Viscosity MESH: Hemorheology Body Fluids Chemistry medicine.anatomical_structure Female Anatomy Rheology Research Article medicine.drug Adult Adolescent Patients Anemia Sickle Cell Research and Analysis Methods MESH: Erythrocyte Aggregation/drug effects Continuum Mechanics MESH: Multivariate Analysis Young Adult Autosomal Recessive Diseases medicine Adults Clinical Genetics business.industry Sickle cell disease Infant Newborn MESH: Male Chemical Properties Multivariate analysis Age Groups People and Places business 030215 immunology |
| Zdroj: | PLoS ONE PLoS ONE, Public Library of Science, 2016, 11 (6), pp.e0158182. ⟨10.1371/journal.pone.0158182⟩ PLoS ONE, Vol 11, Iss 6, p e0158182 (2016) PLoS ONE, Public Library of Science, 2016, 11 (6), ⟨10.1371/journal.pone.0158182⟩ |
| ISSN: | 1932-6203 |
| Popis: | Objectives Blood rheology plays a key role in the pathophysiology of sickle cell anaemia (SS) and sickle cell haemoglobin C disease (SC), but its evolution over the lifespan is unknown. Materials and Methods Blood viscosity, red blood cell (RBC) deformability and aggregation, foetal haemoglobin (HbF) and haematocrit were measured in 114 healthy individuals (AA), 267 SS (161 children + 106 adults) and 138 SC (74 children + 64 adults) patients. Results Our results showed that 1) RBC deformability is at its maximal value during the early years of life in SS and SC populations, mainly because HbF level is also at its peak, 2) during childhood and adulthood, hydroxycarbamide treatment, HbF level and gender modulated RBC deformability in SS patients, independently of age, 3) blood viscosity is higher in older SS and SC patients compared to younger ones and 4) haematocrit decreases as SS patients age. Conclusion The hemorheological changes detected in older patients could play a role in the progressive development of several chronic disorders in sickle cell disease, whose prevalence increases with age. Retarding these age-related haemorheological impairments, by using suitable drugs, may minimize the risks of vaso-occlusive events and chronic disorders. |
| Databáze: | OpenAIRE |
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