Gastric Mixed Adenoneuroendocrine Carcinoma Occurring 50 Years after a Gastroenterostomy with Braun Anastomosis
| Autor: | Takahiro Umemoto, Taketo Matsubara, Gaku Kigawa, Kazuaki Yokomizo, Genshu Tate, Junichi Tanaka, Akihiko Matsumiya, Hiroshi Nemoto, Hiroki Mizukami |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
medicine.medical_specialty
Pathology medicine.medical_treatment Gastric Mixed Adenoneuroendocrine Carcinoma Anastomosis Gastroenterology lcsh:RC254-282 Published online: May 2014 Bile reflux Internal medicine Mixed adenoneuroendocrine carcinoma medicine Gastric mucosa Braun enteroenterostomy business.industry Cancer medicine.disease Gastroenterostomy lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens digestive system diseases medicine.anatomical_structure Oncology Tubular Adenocarcinoma Neuroendocrine carcinoma Adenocarcinoma business |
| Zdroj: | Case Reports in Oncology, Vol 7, Iss 2, Pp 330-336 (2014) Case Reports in Oncology |
| ISSN: | 1662-6575 |
| Popis: | A 75-year-old man was diagnosed with gastric cancer. Fifty years previously, he had undergone gastroenterostomy with a Braun enteroenterostomy. At present, a distal gastrectomy and small intestinal partial resection were performed. Intraoperatively, the tumor was localized to the previous stomal site. HE staining showed that the tumor comprised two elements: a tubular adenocarcinoma on the gastric side and a neuroendocrine carcinoma (NEC) on the jejunal side. The final pathologic diagnosis was mixed adenoneuroendocrine carcinoma based on an immunohistochemical analysis of endocrine markers and an elevated Ki-67 labeling index. The risk of later cancer development cancer recurrence near the gastrojejunostomy site is well known. Potentially, chronic enterogastric bile reflux may irritate the gastric mucosa and act as a promoter. Gastric NEC has a strong malignant potential. We suspect that, in the present case, the constant exposure to secondary bile may have induced a gastric mucosal adenocarcinoma, which finally differentiated into a NEC. |
| Databáze: | OpenAIRE |
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