Facile solvothermal synthesis of mesostructured Fe3O4/chitosan nanoparticles as delivery vehicles for pH-responsive drug delivery and magnetic resonance imaging contrast agents
| Autor: | Guanghui Zhao, Xuemei Yuan, Jianzhi Wang, Yanfeng Li, Yingxia Ma, Xiaomen Peng |
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| Rok vydání: | 2013 |
| Předmět: |
Reducing agent
Cell Survival Solvothermal synthesis Nanoparticle Contrast Media macromolecular substances Biochemistry Chitosan chemistry.chemical_compound Organic chemistry Molecule Humans Drug Carriers Antibiotics Antineoplastic Organic Chemistry technology industry and agriculture General Chemistry Hydrogen-Ion Concentration Magnetic Resonance Imaging Ferrosoferric Oxide carbohydrates (lipids) Zinc chemistry Chemical engineering Doxorubicin Drug delivery Nanoparticles Ethylene glycol Ammonium acetate Porosity HeLa Cells |
| Zdroj: | Chemistry, an Asian journal. 9(2) |
| ISSN: | 1861-471X |
| Popis: | We report a facile fabrication of a host-metal-guest coordination-bonding system in a mesostructured Fe3O4/chitosan nanoparticle that can act as a pH-responsive drug-delivery system. The mesostructured Fe3O4/chitosan was synthesized by a solvothermal approach with iron(III) chloride hexahydrate as a precursor, ethylene glycol as a reducing agent, ammonium acetate as a porogen, and chitosan as a surface-modification agent. Subsequently, doxorubicin (DOX), acting as a model drug (guest), was loaded onto the mesostructured Fe3O4/chitosan nanoparticles, with chitosan acting as a host molecule to form the NH2-Zn(II)-DOX coordination architecture. The release of DOX can be achieved through the cleavage of coordination bonds that are sensitive to variations in external pH under weakly acidic conditions. The pH-responsive nature of the nanoparticles was confirmed by in vitro releases and cell assay tests. Furthermore, the relaxation efficiency of the nanoparticles as high-performance magnetic resonance imaging contrast agents was also investigated. Experimental results confirm that the synthesized mesostructured Fe3O4/chitosan is a smart nanovehicle for drug delivery owing to both its pH-responsive nature and relaxation efficiency. |
| Databáze: | OpenAIRE |
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