The false-positive and false-negative predictive value of HIV antibody test in the Chinese population
| Autor: | Pei Liu, Yudong Dai, Haitao Yang, Yuepu Pu, Lei Li, Cannan Wang, Zhixu Shi, Yuanbao Liu, Jinfang Sun |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
medicine.medical_specialty
China Population Blotting Western Human immunodeficiency virus (HIV) Blood Donors Enzyme-Linked Immunosorbent Assay HIV Antibodies medicine.disease_cause Acquired immunodeficiency syndrome (AIDS) Asian People HIV Seroprevalence Pregnancy Internal medicine HIV Seropositivity HIV ANTIBODY TEST Prevalence Medicine Humans education education.field_of_study Chinese population business.industry Health Policy Public Health Environmental and Occupational Health medicine.disease Predictive value Blood donor Immunology HIV-2 HIV-1 Female business |
| Zdroj: | Journal of medical screening. 15(2) |
| ISSN: | 0969-1413 |
| Popis: | Objectives To analyse the relationship between the false-positive/false-negative predictive value (FPPV/FNPV) of the HIV-antibody (HIV-Ab) test and prevalence in different Chinese population groups. Methods HIV prevalence among different population groups was obtained by a screening survey of blood donors and the national HIV/AIDS surveillance programme in China. Given the sensitivity and specificity of a test kit and the prevalence of HIV infection, the estimated values of FPPV/FNPV were calculated using Bayes' formula. The actual value of FPPV of blood donors was obtained by screening 1,195,286 blood donors. Results This study indicates that the FPPV of HIV-Ab enzyme-linked immunosorbent assay (ELISA) assays varies widely in different Chinese populations: about 99.5% in the blood donor population, but only 3.2% in the injecting-drug users in high-risk areas. In 1,195,286 sera specimens from the blood donors, 2439 specimens were HIV-Ab positive by third ELISA, and 11 HIV cases were confirmed by Western blot. The HIV prevalence of the blood donor population in this survey was 0.0009% (11/1,195,286), but the HIV-Ab positive rate of third ELISA is 0.2% (2439/1,195,286) and 222 times higher than the prevalence. Conclusions Evaluation of HIV prevalence through the HIV-Ab positive rate by third ELISA will significantly overestimate the true prevalence in a low-prevalence population. Individual HIV-infection status should be taken into consideration when analysing the results of HIV-Ab tests in a population with low infection. |
| Databáze: | OpenAIRE |
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