Premalignant changes in normal appearing epithelium in patients with squamous cell carcinoma of the upper aerodigestive tract
| Autor: | Boonchu Kulapaditharom, M. Stuart Strong, Joseph Incze, Charles W. Vaughan, Peter Lui |
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| Rok vydání: | 1982 |
| Předmět: |
Adult
Risk Pathology medicine.medical_specialty Digestive System Neoplasms medicine.disease_cause Epithelium law.invention law Biopsy medicine Humans In patient Carcinogen medicine.diagnostic_test business.industry Mouth Mucosa Mucous membrane Tobacco Use Disorder General Medicine Middle Aged Respiratory Tract Neoplasms Upper aerodigestive tract medicine.anatomical_structure Carcinoma Squamous Cell Mouth Neoplasms Surgery Electron microscope Carcinogenesis business Precancerous Conditions |
| Zdroj: | The American Journal of Surgery. 144:401-405 |
| ISSN: | 0002-9610 |
| DOI: | 10.1016/0002-9610(82)90411-1 |
| Popis: | Biopsy specimens of “normal” mucous membrane of patients susceptible to the effects of the carcinogens of tobacco revealed morphologic abnormalities on electron microscopic examination that were consistent with the concept that carcinogenesis is a multistep process of sequential neoplastic development extending over a long period of time. Such changes in the upper aerodigestive tract are probably tobacco induced and may be reversible if tobacco exposure is eliminated. Use of the electron microscope can provide the clinician with an accurate assay of the severity of mucosal alterations induced by tobacco. The ability to detect such morphologic abnormalities should provide another deterrant to smoking and a useful tool in the further study of these phenomena. |
| Databáze: | OpenAIRE |
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