| Popis: |
When administered to hamsters twice daily on days 4, 5 and 6 of pregnancy, PGF2α is highly effective in terminating gestation. The response is all-or-none, pregnancies either being completely stopped or continuing with no change in status of the conceptus. The ED50 for termination of pregnancy is estimated at 1.75 μg (per each of the 6 injections). The method is a highly satisfactory assay for PG's, as judged by the effects of PGF2α. Single injections on days 5, 6 or 7 also terminate pregnancies. Although this approach has not been fully quantified, it may lend itself to a suitable assay procedure with some saving of compound and labor. |
