Risk of acute gastroenteritis associated with human bocavirus infection in children: A systematic review and meta-analysis

Autor: Ru-nan Zhu, Linqing Zhao, Yuan Qian, Jie Deng, Fang Wang, Liying Liu, Liping Jia, Yu Sun, Huijin Dong, Ri De
Rok vydání: 2017
Předmět:
0301 basic medicine
Male
Viral Diseases
lcsh:Medicine
Cochrane Library
Pediatrics
Families
Database and Informatics Methods
Mathematical and Statistical Techniques
Human bocavirus
Genotype
Prevalence
Medicine and Health Sciences
Database Searching
lcsh:Science
Children
Multidisciplinary
biology
Research Assessment
Human Bocavirus Infection
Gastroenteritis
Systematic review
Infectious Diseases
Meta-analysis
Child
Preschool
Physical Sciences
Female
Pediatric Infections
Statistics (Mathematics)
Research Article
medicine.medical_specialty
Systematic Reviews
030106 microbiology
Gastroenterology and Hepatology
Research and Analysis Methods
Parvoviridae Infections
03 medical and health sciences
Internal medicine
medicine
Humans
Risk factor
Statistical Methods
business.industry
lcsh:R
Infant
Newborn
Infant
Odds ratio
biology.organism_classification
Confidence interval
Age Groups
People and Places
lcsh:Q
Population Groupings
business
Mathematics
Meta-Analysis
Zdroj: PLoS ONE
PLoS ONE, Vol 12, Iss 9, p e0184833 (2017)
ISSN: 1932-6203
Popis: Human bocaviruses (HBoVs), which were first identified in 2005 and are composed of genotypes 1-4, have been increasingly detected worldwide in pediatric patients with acute gastroenteritis. To investigate if HBoV infection is a risk factor of acute gastroenteritis in children younger than 5 years old, we searched PubMed, Embase (via Ovid), the Chinese Biomedical Literature Database (CBM), and the Cochrane Library for studies assessing the prevalence of HBoVs in individuals from Oct 25, 2005 to Oct 31, 2016. We included studies using PCR-based diagnostics for HBoVs from stool specimens of patients with or without acute gastroenteritis that carried out research for over 1 year on pediatric patients aged younger than 5 years old. The primary outcome was the HBoV prevalence among all cases with acute gastroenteritis. Pooled estimates of the HBoV prevalence were then generated by fitting linear mixed effect meta-regression models. Of the 36 studies included, the pooled HBoV prevalence in 20,591 patients with acute gastroenteritis was 6.90% (95% confidence interval (95% CI): 5.80-8.10%). In the ten studies with a control group, HBoVs were detected in 12.40% of the 3,620 cases with acute gastroenteritis and in 12.22% of the 2,030 control children (odds ratio (OR): 1.44; 95% CI: 0.95-2.19, p = 0.09 between case and control groups). HBoV1 and HBoV2 were detected in 3.49% and 8.59% of acute gastroenteritis cases, respectively, and in 2.22% and 5.09% of control children, respectively (OR: 1.40; 95% CI: 0.61-3.25; p = 0.43 and OR: 1.68; 95% CI: 1.21-2.32; p = 0.002, respectively). Current evidence suggests that the overall HBoV prevalence in children younger than 5 years old is not significantly different between groups with or without acute gastroenteritis. However, when HBoV1 was excluded, the HBoV2 prevalence was significantly different between these two groups, which may imply that HBoV2 is a risk factor of acute gastroenteritis in children younger than 5 years old.
Databáze: OpenAIRE
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