Fleece bound sealing prevents pleural adhesions
| Autor: | Ernst Wolner, Seyedhossein Aharinejad, Vladyslav Getman, Elena Devyatko, Michael Rolf Mueller |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
Pulmonary and Respiratory Medicine
medicine.medical_specialty business.industry Experimental model Parietal Pleura medicine.medical_treatment Serous membrane TachoSil Pleural adhesions Surgery Mesothelium Experimental animal medicine.anatomical_structure Medicine Thoracotomy Cardiology and Cardiovascular Medicine business |
| Zdroj: | Interactive cardiovascular and thoracic surgery. 5(3) |
| ISSN: | 1569-9285 |
| Popis: | This study assessed the value of haemostatic fleece (HF) in prevention of pleural adhesions in an experimental animal model. Forty rats were randomly assigned to four equal groups and underwent bilateral thoracotomy. In Group 1 standardized defects of 5 mm were generated in the visceral and the opposite parietal pleura without further coverage. In Group 2 a 5-mm piece of HF (TachoSil) was applied onto the intact pleura. In Group 3 a standardized pleural defect was completely covered by HF. The same kind of defect was only partially covered by HF in group 4 animals. Autopsy at 6 weeks (n=5, each group) revealed the fleece widely unchanged and covered by a smooth serous membrane. After 12 weeks (n=5, each group) the fleece had been completely resorbed. Histological studies revealed the area of the defect covered by regular mesothelium. In all animals pleural adhesions were detected only in the area without fleece coverage. In this experimental model HF prevented the development of pleural adhesions. This property may have clinical impact in patients with some probability of re-thoracotomy enabling to reduce the risk of pleural adhesions significantly. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|