Does the Insulin-Like Growth Factor System Interact with Prostaglandins and Proinflammatory Cytokines During Neurodegeneration?
| Autor: | Donald M. Henricks, Sandra L. Gray, Brett R. Lackey |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Programmed cell death
medicine.medical_specialty Interleukins medicine.medical_treatment Neurodegeneration Disease Biology medicine.disease General Biochemistry Genetics and Molecular Biology Proinflammatory cytokine Insulin-like growth factor Endocrinology Alzheimer Disease Somatomedins Apoptosis Internal medicine Nerve Degeneration Prostaglandins medicine Reactive oxygen species generation Animals Cytokines Humans Tumor necrosis factor alpha Down Syndrome |
| Zdroj: | Proceedings of the Society for Experimental Biology and Medicine. 224:20-27 |
| ISSN: | 1525-1373 0037-9727 |
| Popis: | Prostaglandins and proinflammatory cytokines are implicated in the etiology of neurodegenerative diseases, such as Alzheimer's disease. Signaling cascades initiated by these factors may result in reactive oxygen species generation and cell death. The insulin-like growth factors (IGF) are ubiquitous polypeptides involved in all aspects of growth and development. Additionally, the IGF are regarded as survival factors that display potent antiapoptotic activity. Interfering with IGF production, distribution, or signaling may result in greater susceptibility to apoptotic stimuli. In neurodegenerative conditions, the IGF appear to be antagonized by prostaglandins and proinflammatory cytokines. In this review, the relationship among specific prostaglandins, the proinflammatory factors, tumor necrosis factor, interleukin-1, and interleukin-6, and the IGF system will be investigated. |
| Databáze: | OpenAIRE |
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