Can glutamine and growth hormone promote protein anabolism in children with cystic fibrosis?
| Autor: | Dominique Darmaun, D. Schaeffer, Valerie Hayes, Jaya Punati, Nelly Mauras |
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| Rok vydání: | 2002 |
| Předmět: |
Male
medicine.medical_specialty Anabolism Cystic Fibrosis Endocrinology Diabetes and Metabolism Glutamine Biology Growth hormone Cystic fibrosis law.invention Endocrinology law Leucine Internal medicine medicine Protein biosynthesis Humans Child Protein anabolism Carbon Isotopes Human Growth Hormone Human growth hormone medicine.disease Bicarbonates Kinetics Protein Biosynthesis Pediatrics Perinatology and Child Health Recombinant DNA Female Oxidation-Reduction |
| Zdroj: | Hormone research. 58 |
| ISSN: | 0301-0163 |
| Popis: | To determine whether recombinant human growth hormone (rhGH), glutamine (GLN) or a combination of both agents can enhance protein synthesis in cystic fibrosis (CF) patients, six 9.6 ± 0.5-year-old prepubertal children (4 M, 2 F) with CF and stable lung disease with undernutrition (weight/height 13C-leucine were used to assess leucine appearance rate (Ra, an index of protein breakdown), oxidation (Ox), and non-oxidative leucine disposal (NOLD, an index of protein synthesis). Results are expressed as changes (%) from baseline:We conclude that in children with CF: (1) due to high inter-subject variability, oral glutamine does not significantly enhance protein gain; (2) rhGH has significant anabolic effects which are mediated by stimulation of protein synthesis, and (3) glutamine does not enhance the effect of rhGH. |
| Databáze: | OpenAIRE |
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