Examination of the brain natriuretic peptide rs198389 single-nucleotide polymorphism on type 2 diabetes mellitus and related phenotypes in an Algerian population
| Autor: | Sounnia Mediene-Benchekor, Aline Meirhaeghe, I. Hamani-Medjaoui, Hadjira Ouhaibi-Djellouli, Philippe Amouyel, Houssam Boulenouar, Djabaria Naïma Meroufel, Leila Houti, Sarah Aïcha Lardjam-Hetraf, Xavier Hermant, Benjamin Grenier-Boley, Louisa Goumidi, Nadhira Saidi-Mehtar |
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| Rok vydání: | 2015 |
| Předmět: |
Adult
Male Risk medicine.medical_specialty medicine.medical_treatment Population Single-nucleotide polymorphism Biology Polymorphism Single Nucleotide Gene Frequency Polymorphism (computer science) Internal medicine Natriuretic Peptide Brain Genetics medicine Humans Insulin SNP Genetic Predisposition to Disease education Genetic Association Studies Genetic association education.field_of_study Type 2 Diabetes Mellitus General Medicine Odds ratio Middle Aged Phenotype Endocrinology Diabetes Mellitus Type 2 Algeria Case-Control Studies Female Insulin Resistance |
| Zdroj: | Gene. 567:159-163 |
| ISSN: | 0378-1119 |
| Popis: | article i nfo Background: In European populations, the NPPB rs198389 single nucleotide polymorphism (SNP) is associated with a reduced risk of type 2 diabetes mellitus (T2DM). We investigated the putative associations between NPPB rs198389, the T2DM risk and quantitative metabolic traits in an Algerian population. Methods:The association analysis was performed as a T2DM case-control study (with 78 cases and 645 controls) nested into the ISOR population-based study. Results: TheNPPBrs198389SNP wasnotassociatedwith T2DM(odds ratio(OR)(95%confidence interval (CI))= 0.73 (0.51-1.04), p = 0.08). However, the C allele was associated with lower fasting plasma insulin levels (p = 0.05) and a lower homeostaticmodel assessmentinsulin resistance index (p= 0.05) innon-diabeticindividuals. Conclusion: The NPPB rs198389 SNP might modulate fasting insulin levels in an Algerian population. |
| Databáze: | OpenAIRE |
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