Pleural mesothelioma of connective tissue type, localized fibrous tumour of the pleura, and reactive submesothelial hyperplasia. An immunohistochemical comparison
| Autor: | B. Corrin, Moutaiz Al‐Izzi, Nicola P. Thurlow |
|---|---|
| Rok vydání: | 1989 |
| Předmět: |
Mesothelioma
Pathology medicine.medical_specialty Pleural Neoplasms Respiratory disease Connective tissue Granulation tissue Vimentin respiratory system Hyperplasia Biology medicine.disease Immunohistochemistry Antibodies respiratory tract diseases Pathology and Forensic Medicine Cytokeratin medicine.anatomical_structure medicine biology.protein Humans Fibroma Connective Tissue Diseases |
| Zdroj: | The Journal of pathology. 158(1) |
| ISSN: | 0022-3417 |
| Popis: | Ten diffuse pleural mesotheliomas of connective tissue type have been compared with 14 examples of pleural granulation tissue and 7 localized fibrous tumours of the pleura, using immunohistochemistry to identify cytokeralins oflow and high molecular weight and vimentin. Low molecular weight cytokeratin and vimentin were both delected in 8 of the 10 mesotheliomas and in 12 of the 14 reactive iesions. High molecular weight cylokeratin was rarely detected in either lesion. The seven localized fibrous tumours of the pleura were all positive for virnentin and negative for both cytokeratins. These findings support an origin of connective tissue type mesotheliomas from multipotential submesothelial spindle cells and of localized fibrous tumours of the pleura from either conventional fibroblasts or resting submesothelial spindle cells. Antibodies to cytokeratin help distinguish these two neoplasms but provide no assistance in the more difficult diagnostic problem of distinguishing mesotheliomas of connective tissue type from pleural reactions characterized by abundant granulation tissue. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text