Topography of microglial activation in sensory- and affect-related brain regions in chronic pain
| Autor: | Anna M.W. Taylor, Catherine M. Cahill, Alison J. Taylor, Sadaf Mehrabani, Steve Liu |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Male Thalamus Sensory system Amygdala Functional Laterality Article 03 medical and health sciences Cellular and Molecular Neuroscience Mice 0302 clinical medicine Peripheral Nerve Injuries medicine Animals Sensory cortex RNA Messenger Calcium-Binding Proteins Microfilament Proteins Chronic pain Brain medicine.disease Spinal cord Mice Inbred C57BL Disease Models Animal 030104 developmental biology medicine.anatomical_structure Neuropathic pain Peripheral nerve injury Microglia Chronic Pain Psychology Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Journal of neuroscience research. 95(6) |
| ISSN: | 1097-4547 |
| Popis: | Microglial activation in the spinal cord plays a central role in the development and maintenance of chronic pain after a peripheral nerve injury (PNI). There has not yet been a thorough assessment of microglial activation in brain regions associated with pain and reward. To this end, this study uses a mouse model of neuropathic pain in which the left sciatic nerve of male C57Bl/6J mice is loosely constricted (chronic constriction injury) to assess microglial activation in several brain regions 2 weeks after injury, a time point at which pain hypersensitivity is well established. We found significant microglial activation in brain regions associated with sensory pain transmission and affect, including the thalamus, sensory cortex, and amygdala. Activation was consistently most robust in brain regions contralateral to the side of injury. Brain regions not directly involved in either sensory or affective dimensions of pain, such as the motor cortex, did not display microglial activation. This study confirms that PNI induces microglial activation in regions involved with both sensory and affective components of pain. © 2016 Wiley Periodicals, Inc. |
| Databáze: | OpenAIRE |
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