MiR-9, miR-21, and miR-155 as potential biomarkers for HPV positive and negative cervical cancer
| Autor: | Hyeeun Bang, Kwang Hwa Park, Jungho Kim, Sunyoung Park, Dongsup Lee, Kiyoon Eom, Hyeyoung Lee, Geehyuk Kim, Sunghyun Kim, Sungwoo Ahn, Hye Young Wang, Hyoungsoon Jang |
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| Rok vydání: | 2017 |
| Předmět: |
Adult
0301 basic medicine Oncology Cancer Research medicine.medical_specialty Papillomavirus E7 Proteins Gene Expression Uterine Cervical Neoplasms lcsh:RC254-282 miR-155 03 medical and health sciences 0302 clinical medicine Surgical oncology Internal medicine microRNA Biomarkers Tumor Genetics Humans Medicine Epigenetics Early Detection of Cancer Cause of death Cervical cancer business.industry HPV Positive RT-qPCR Papillomavirus Infections HPV infection Middle Aged lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens medicine.disease MicroRNAs 030104 developmental biology ROC Curve 030220 oncology & carcinogenesis Carcinoma Squamous Cell Female Molecular diagnosis HPV E6/E7 business Research Article |
| Zdroj: | BMC Cancer BMC Cancer, Vol 17, Iss 1, Pp 1-8 (2017) |
| ISSN: | 1471-2407 |
| DOI: | 10.1186/s12885-017-3642-5 |
| Popis: | Background Cervical cancer is the second leading cause of death among female patients with cancer in the world. High risk human papillomavirus has causal roles in cervical cancer initiation and progression by deregulating several cellular processes. However, HPV infection is not sufficient for cervical carcinoma development. Therefore, other genetic and epigenetic factors may be involved in this complex disease, and the identification of which may lead to better diagnosis and treatment. Our aim was to analyze the expression of microRNAs in cervical cancer cases positive or negative for HPV E6/E7 mRNA, and to assess their diagnostic usefulness and relevance. Methods The expression of three different microRNAs (miR-9, miR-21, and miR-155) in 52 formalin-fixed paraffin-embedded (FFPE) primary cervical cancer tissue samples and 50 FFPE normal cervical tissue samples were evaluated. Results MiR-9, miR-21, and miR-155 were significantly overexpressed in cervical cancer tissues compared to normal tissues (P |
| Databáze: | OpenAIRE |
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