Enhanced replication of R5 HIV-1 isolates in vitro by a small-molecule reagent targeting HIV-1 protease

Autor:	Nick J. Wardle, Ray W. Matthews, Harry R. Hudson, S. W. Annie Bligh, Cherelyn Vella, Christine M. Nunn
Rok vydání:	2013
Předmět:	Chemokine medicine.medical_treatment Microbial Sensitivity Tests Biology Virus Replication Biochemistry Small Molecule Libraries Structure-Activity Relationship HIV-1 protease HIV Protease Drug Discovery medicine General Pharmacology Toxicology and Pharmaceutics Pharmacology Protease Dose-Response Relationship Drug Molecular Structure Organic Chemistry HIV Protease Inhibitors Small molecule Virology In vitro Viral replication Drug development Reagent biology.protein HIV-1 Molecular Medicine
Zdroj:	ChemMedChem. 8(5)
ISSN:	1860-7187
Popis:	Chemical enhancement: Designed to target HIV-1 protease, a novel ?-hydroxyphosphonate has been found to significantly enhance viral replication in a panel of clinically relevant R5 HIV-1 isolates. This unexpected result constitutes the first instance of a small molecule capable of doing this, and it has implications for the preparation and use of R5 isolates in vaccine and drug development.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b82f55c1e7fc010e079e795b82985f4 https://pubmed.ncbi.nlm.nih.gov/23509042 Zobrazit plný text záznamu Plný text